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Rosa, Ellen Perim; Murakami-Malaquias-da-Silva, Felipe; Palma-Cruz, Marlon; de Carvalho Garcia, Geovana; Brito, Auriléia Aparecida; Andreo, Lucas; Kamei, Sergio Koiti; Negreiros, Renata Matalon; Rodrigues, Maria Fernanda De Souza Setubal Destro; Mesquita-Ferrari, Raquel Agnelli; Bussadori, Sandra Kalil; Fernandes, Kristianne Porta Santos; Ligeiro-de-Oliveira, Ana Paula; Lino-Dos-Santos-Franco, Adriana; Horliana, Anna Carolina Ratto Tempestini
Life sciences (1973), 11/2020, Volume: 261Journal Article
The aim of this study was to verify the impact of periodontitis in the course of chronic obstructive pulmonary disease (COPD) in C57Bl/6J mice. The animals were randomly divided into four groups (n = 8): Basal, Periodontitis (P), COPD and COPD+P. COPD was induced by orotracheal instillation of 30 μl of cigarette extract 3 times/week for 7 weeks. Periodontitis was induced by ligation technique for 22 days. Euthanasia was performed on 51st day. The analyzes were total/differential cells and cytokines recovered from bronchoalveolar lavage (BAL), total/differential blood cell count, platelets, total marrow cell count, airway collagen deposition, alveolar enlargement analyzed by mean linear intercept (Lm), mucus and bone crest reabsorption. One-way ANOVA followed by the Student-Newman-Keuls was used. The association COPD+P decreased macrophages (p = 0,0351), TNF-α (p = 0,0071) and INF-γ (p = 0,0004) in BAL, when compared to the COPD group maintaining emphysema levels by alveolar enlargement (p < .05) reorganization of collagen fibers (p = .001) and also mean linear intercept (lm) (p = .001) and mucus (p = .0001). The periodontitis group caused TNF-α increase (p = 0, 0001) in BAL. Periodontitis, per se, does not alter any of the parameters analyzed, except for increased TNF-α in BAL. However, its association with COPD caused macrophages TNF-α and INF-γ alterations, when compared to the COPD group maintaining emphysema levels by alveolar enlargement and reorganization of collagen fibers. It seems that periodontitis is influencing the course of Th1 profile cell, and cytokines and pulmonary alterations. Further studies are needed to clarify the regulatory process underlying these two diseases.
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