Although well theorized at the individual level, previous research has neglected the role of national context in shaping overall levels of nonwork–work and work–nonwork interference. This study fills this gap by examining how a national context of gender empowerment affects the likelihood of experiencing nonwork–work and work–nonwork interference at the individual and national levels. Controlling for individual-level differences in the distribution of job demands and resources, results from our multilevel models indicate that women’s empowerment has significant net gender and parenthood effects on nonwork–work interference. By contrast, gender empowerment equally structures work–nonwork interference for these groups. Our results highlight the need to investigate interference bidirectionally and in a multilevel context.