Who drives regional economic development in entrepreneurial ecosystems of different types? Using longitudinal data on 267 NUTS-3 European regions during the period 2008-16, we apply the entrepreneurial ecosystem theoretical framework to study how entrepreneurial ecosystem type moderates the relationship between a variety of entrepreneurship and regional economic development. It is found that regional economic development proxied by gross value added per resident responds differently to solo self-employment, job creators and new-firm birth rates as well as changes in a share of productive high-growth entrepreneurship across different entrepreneurial ecosystems. The findings have implications for regional and national policy-makers and scholars who study the geography of entrepreneurship.