This study aimed to investigate the expressions of secreted frizzled-related protein 1 (sFRP1) and β-catenin in cervical cancer and cervical intraepithelial neoplasia (CIN), and to explore the relationship between both proteins and the prognosis of cervical cancer. Immunohistochemistry was performed to detect the protein expressions of sFRP1 and β-catenin in cervical cancer (n=78), CIN (n=30) and normal cervical tissues (n=20), and the relationships of sFRP1 and β-catenin with the clinicopathological characteristics and prognosis of cervical cancer were analyzed. The positive rate of sFRP1 was 100%, 70% and 33.3% in the normal cervical tissues, CIN and cervical cancer, respectively (P<0.05). The sFRP1 expression was positively correlated with the stage of cervical cancer and lymphatic metastasis (P<0.05). The 5-year survival rate was significantly higher in patients positive for sFRP1 than in those negative for sFRP1 (P<0.05). The rate of abnormal β-catenin expression in the normal cervical tissues, CIN and cervical cancer was 5%, 43.3% and 70.5%, respectively (P<0.05). The abnormal β-catenin expression was positively correlated with the stage of cervical cancer, lymphatic metastasis and pathological grade (P<0.05). The 5-year survival rate was markedly higher in patients with normal β-catenin expression than in those with abnormal β-catenin expression (P<0.05). The sFRP1 expression was negatively related to the β-catenin expression in cervical cancer (r = -0.557, P<0.001). Both sFRP1 and β-catenin play important roles in the initiation and development of cervical cancer, and both proteins can be used as indicators predicting the prognosis of cervical cancer. U ovoj studiji ispitivana je ekspresija sFRP1 i β-katenina u karcinomu grlića materice i cervikalnoj intra-epitelnoj neoplaziji (CIN), kao i odnos između ova dva proteina i prognoze u karcinomu grlića materice. Imunohisto-hemijskim putem utvrđena je ekspresija proteina sFRP1 i β-katenina u karcinomu grlića materice (n=78), CIN (n=30) i zdravom cervikalnom tkivu (n=20). Analizirana je povezanost sFRP1 i β-katenina sa kliničko-patološkim karakteristikama i prognozom u karcinomu grlića materice. Pozitivna stopa sFRP1 bila je 100%, 70% i 33,3% u zdravim cervikalnim tkivima, CIN i karcinomu grlića materice (p<0,05). Ekspresija sFRP1 pozitivno je korelisala sa stadijumom karcinoma grlića materice i limfnim metastazama (p<0,05). Stopa petogodišnjeg preživljavanja bila je značajno viša kod pacijenata pozitivnih na sFRP1 nego kod onih kod kojih je sFRP1 bio negativan (p<0,05). Stopa abnormalne ekspresije β-katenina u zdravim cervikalnim tkivima, CIN i karcinomu grlića materice bila je 5%, 43,3% i 70,5% (p<0,05). Abnormalna ekspresija β-katenina bila je u pozitivnoj korelaciji sa stadijumom karcinoma grlića materice, limfnim metastazama i patološkim stepenom (p<0,05). Stopa peto-godišnjeg preživljavanja bila je izrazito viša kod pacijenata sa normalnom ekspresijom β-katenina u odnosu na one sa abnormalnom ekspresijom β-katenina (p<0,05). Ekspresija sFRP1 bila je u negativnom odnosu sa ekspresijom β-katenina u karcinomu grlića materice (r= -0,557, p<0,01). I sFRP1 i β-katenin igraju važne uloge u nastanku i razvoju karcinoma grlića materice i oba proteina se mogu upotrebljavati kao pokazatelji u predviđanju prognoze kod obolelih od karcinoma grlića materice.