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  • Recent progress towards gol...
    Pan, Fei; Shu, Chao; Ye, Long-Wu

    Organic & biomolecular chemistry, 10/2016, Volume: 14, Issue: 4
    Journal Article

    N-Containing tricyclic compounds, especially the tricyclic N-heterocycles, are important structural motifs that possess significant potential in organic chemistry for their momentous applications in natural and man-made bioactive molecules. Gold catalysis, which exhibits specific catalytic properties in terms of both high reactivity and selectivity for various organic transformations, has proven to be a powerful tool for the straightforward synthesis of cyclic compounds, especially the polycyclic molecules. Currently, several approaches towards polycycle synthesis have been developed via gold-catalyzed transformations of readily available ynamides. In this review, we will focus on the recent advances in the gold-catalyzed construction of N-containing tricycles based on ynamides by highlighting their specificity and applicability, and the mechanistic rationale is presented where possible. The recent advances in the gold-catalyzed construction of N-containing tricycles based on ynamides are reviewed by highlighting their specificity and applicability, and the mechanistic rationale.