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Yan, Hui; Zhu, Kongfu; Teng, Maikun; Li, Xu
FEBS letters, February 2020, Volume: 594, Issue: 4Journal Article
Cyclobutane pyrimidine dimers (CPD), as a common DNA damage caused by UV radiation, often lead to skin cancer. Here, we identified a photolyase from the alga Arthrospira platensis (designated as Ap‐phr), which has been regarded as a safe organism for humans for centuries, that can efficiently repair CPD lesions in ssDNA and dsDNA in vitro. The 1.6 Å resolution crystal structure of Ap‐phr revealed that it possesses a unique methenyltetrahydrofolate chromophore‐binding pattern with high energy transfer efficiency. Our study of Ap‐phr highlights its potential use in cosmetic, industrial and aesthetic medicine applications.
