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Solanich, Xavier; Rigo-Bonnin, Raúl; Gumucio, Victor-David; Bastard, Paul; Rosain, Jérémie; Philippot, Quentin; Perez-Fernandez, Xosé-Luis; Fuset-Cabanes, Maria-Paz; Gordillo-Benitez, Miguel-Ángel; Suarez-Cuartin, Guillermo; Boza-Hernandez, Enric; Riera-Mestre, Antoni; Parra-Martínez, Alba; Colobran, Roger; Antolí, Arnau; Navarro, Sergio; Rocamora-Blanch, Gemma; Framil, Mario; Calatayud, Laura; Corbella, Xavier; Casanova, Jean-Laurent; Morandeira, Francisco; Sabater-Riera, Joan
Journal of clinical immunology, 11/2021, Volume: 41, Issue: 8Journal Article
Background It is important to predict which patients infected by SARS-CoV-2 are at higher risk of life-threatening COVID-19. Several studies suggest that neutralizing auto-antibodies (auto-Abs) against type I interferons (IFNs) are predictive of critical COVID-19 pneumonia. Objectives We aimed to test for auto-Abs to type I IFN and describe the main characteristics of COVID-19 patients admitted to intensive care depending on whether or not these auto-Abs are present. Methods Retrospective analysis of all COVID-19 patients admitted to an intensive care unit (ICU) in whom samples were available, from March 2020 to March 2021, in Barcelona, Spain. Results A total of 275 (70.5%) out of 390 patients admitted to ICU were tested for type I IFNs auto-antibodies (α2 and/or ω) by ELISA, being positive in 49 (17.8%) of them. Blocking activity of plasma diluted 1/10 for high concentrations (10 ng/mL) of IFNs was proven in 26 (9.5%) patients. Almost all the patients with neutralizing auto-Abs were men (92.3%). ICU patients with positive results for neutralizing IFNs auto-Abs did not show relevant differences in demographic, comorbidities, clinical features, and mortality, when compared with those with negative results. Nevertheless, some laboratory tests (leukocytosis, neutrophilia, thrombocytosis) related with COVID-19 severity, as well as acute kidney injury (17 65.4% vs. 100 40.2%; p = 0.013) were significantly higher in patients with auto-Abs. Conclusion Auto-Abs neutralizing high concentrations of type I IFNs were found in 9.5% of patients admitted to the ICU for COVID-19 pneumonia in a hospital in Barcelona. These auto-Abs should be tested early upon diagnosis of SARS-CoV-2 infection, as they account for a significant proportion of life-threatening cases.
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