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Noble, Carl W.; Gangaputra, Sapna S.; Thompson, Ian A.; Yuan, Amy; Apolo, Andrea B.; Lee, Jung-Min; Papaliodis, George N.; Kodati, Shilpa; Bishop, Rachel; Magone, M. Teresa; Sobrin, Lucia; Sen, H. Nida
Ocular immunology and inflammation, 08/2020, Volume: 28, Issue: 6Journal Article
To report the clinical features, severity, and management of ocular immune-related adverse events (irAEs) in the setting of immune checkpoint inhibitor therapy for metastatic malignancies. Retrospective chart review at three tertiary ophthalmology clinics. Electronic medical records were reviewed between 2000 and 2017 for patients with new ocular symptoms while undergoing checkpoint inhibition therapy. Eleven patients were identified. Ocular irAEs ranged from keratoconjunctivitis sicca to Vogt-Koyanagi-Harada-like findings. Average timing of irAEs from starting checkpoint inhibitor therapy was 15.7 weeks. Ocular inflammation was successfully controlled with corticosteroids in most cases, however three patients discontinue treatment as a result of ocular inflammation with decreased visual acuity, two discontinued due to progression of metastatic disease, and one discontinued due to severe systemic irAEs. We found a wide spectrum of ocular irAEs associated with immune checkpoint inhibitors. In most cases, ocular AEs did not limit ongoing cancer treatment.
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