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Ma, Shaojie; Skarica, Mario; Li, Qian; Xu, Chuan; Risgaard, Ryan D; Tebbenkamp, Andrew T N; Mato-Blanco, Xoel; Kovner, Rothem; Krsnik, Željka; de Martin, Xabier; Luria, Victor; Martí-Pérez, Xavier; Liang, Dan; Karger, Amir; Schmidt, Danielle K; Gomez-Sanchez, Zachary; Qi, Cai; Gobeske, Kevin T; Pochareddy, Sirisha; Debnath, Ashwin; Hottman, Cade J; Spurrier, Joshua; Teo, Leon; Boghdadi, Anthony G; Homman-Ludiye, Jihane; Ely, John J; Daadi, Etienne W; Mi, Da; Daadi, Marcel; Marín, Oscar; Hof, Patrick R; Rasin, Mladen-Roko; Bourne, James; Sherwood, Chet C; Santpere, Gabriel; Girgenti, Matthew J; Strittmatter, Stephen M; Sousa, André M M; Sestan, Nenad
Science (American Association for the Advancement of Science), 09/2022, Volume: 377, Issue: 6614Journal Article
The granular dorsolateral prefrontal cortex (dlPFC) is an evolutionary specialization of primates that is centrally involved in cognition. We assessed more than 600,000 single-nucleus transcriptomes from adult human, chimpanzee, macaque, and marmoset dlPFC. Although most cell subtypes defined transcriptomically are conserved, we detected several that exist only in a subset of species as well as substantial species-specific molecular differences across homologous neuronal, glial, and non-neural subtypes. The latter are exemplified by human-specific switching between expression of the neuropeptide somatostatin and tyrosine hydroxylase, the rate-limiting enzyme in dopamine production in certain interneurons. The above molecular differences are also illustrated by expression of the neuropsychiatric risk gene , which is human-specific in microglia and primate-specific in layer 4 granular neurons. We generated a comprehensive survey of the dlPFC cellular repertoire and its shared and divergent features in anthropoid primates.
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