E-resources
-
Croll, Tristan I.; Smith, Brian J.; Margetts, Mai B.; Whittaker, Jonathan; Weiss, Michael A.; Ward, Colin W.; Lawrence, Michael C.
Structure, 03/2016, Volume: 24, Issue: 3Journal Article
Insulin receptor (IR) signaling is critical to controlling nutrient uptake and metabolism. However, only a low-resolution (3.8 Å) structure currently exists for the IR ectodomain, with some segments ill-defined or unmodeled due to disorder. Here, we revise this structure using new diffraction data to 3.3 Å resolution that allow improved modeling of the N-linked glycans, the first and third fibronectin type III domains, and the insert domain. A novel haptic interactive molecular dynamics strategy was used to aid fitting to low-resolution electron density maps. The resulting model provides a foundation for investigation of structural transitions in IR upon ligand binding. Display omitted •The structure of the insulin receptor ectodomain is improved to 3.3 Å resolution•The structure reveals new features within the receptor insert domain•The structure corrects errors in the first and third fibronectin type III domains•A new low-resolution crystallographic model-building strategy, iMDFF, is presented Croll et al. describe a revised structure of the human insulin receptor ectodomain using diffraction data to 3.3 Å resolution. The revised structure allows improved resolution of the insert domain, an element critical to ligand binding and signal transduction.
![loading ... loading ...](themes/default/img/ajax-loading.gif)
Shelf entry
Permalink
- URL:
Impact factor
Access to the JCR database is permitted only to users from Slovenia. Your current IP address is not on the list of IP addresses with access permission, and authentication with the relevant AAI accout is required.
Year | Impact factor | Edition | Category | Classification | ||||
---|---|---|---|---|---|---|---|---|
JCR | SNIP | JCR | SNIP | JCR | SNIP | JCR | SNIP |
Select the library membership card:
If the library membership card is not in the list,
add a new one.
DRS, in which the journal is indexed
Database name | Field | Year |
---|
Links to authors' personal bibliographies | Links to information on researchers in the SICRIS system |
---|
Source: Personal bibliographies
and: SICRIS
The material is available in full text. If you wish to order the material anyway, click the Continue button.