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Parisi, Maria Candida R; Moura Neto, Arnaldo; Menezes, Fabio H; Gomes, Marilia Brito; Teixeira, Rodrigo Martins; de Oliveira, José Egídio Paulo; Pereira, Joana Rodrigues Dantas; Fonseca, Reine Marie Chaves; Guedes, Lorena Barreto Arruda; Costa E Forti, Adriana; de Oliveira, Ana Mayra Andrade; de Medeiros Nóbrega, Marta Barreto; Colares, Víctor Nóbrega Quintas; Schmid, Helena; Nienov, Otto Henrique; Nery, Marcia; Fernandes, Túlio Diniz; Pedrosa, Hermelinda C; Schreiber de Oliveira, Cristina da S; Ronsoni, Marcelo; Rezende, Karla Freire; Quilici, Maria Teresa Verrone; Vieira, Alexandre Eduardo Franzin; de Macedo, Geisa Maria Campos; Stuchi-Perez, Eliana Gabas; Dinhane, Kandir Genésio Innocenti; Pace, Ana Emilia; de Freitas, Maria Cristina Foss; Calsolari, Maria Regina; Saad, Mario José Abdalla
Diabetology & metabolic syndrome, 03/2016, Volume: 8, Issue: 24Journal Article
Studies on diabetic foot and its complications involving a significant and representative sample of patients in South American countries are scarce. The main objective of this study was to acquire clinical and epidemiological data on a large cohort of diabetic patients from 19 centers from Brazil and focus on factors that could be associated with the risk of ulcer and amputation. This study presents cross sectional, baseline results of the BRAZUPA Study. A total of 1455 patients were included. Parameters recorded included age, gender, ethnicity, diabetes and comorbidity-related records, previous ulcer or amputation, clinical symptomatic score, foot classification and microvascular complications. Patients with ulcer had longer disease duration (17.2 ± 9.9 vs. 13.2 ± 9.4 years; p < 0.001), and poorer glycemic control (HbA1c 9.23 ± 2.03 vs. 8.35 ± 1.99; p < 0.001). Independent risk factors for ulcer were male gender (OR 1.71; 95 % CI 1.2-3.7), smoking (OR 1.78; 95 % CI 1.09-2.89), neuroischemic foot (OR 20.34; 95 % CI 9.31-44.38), region of origin (higher risk for those from developed regions, OR 2.39; 95 % CI 1.47-3.87), presence of retinopathy (OR 1.68; 95 % CI 1.08-2.62) and absence of vibratory sensation (OR 7.95; 95 % CI 4.65-13.59). Risk factors for amputation were male gender (OR 2.12; 95 % CI 1.2-3.73), type 2 diabetes (OR 3.33; 95 % CI 1.01-11.1), foot at risk classification (higher risk for ischemic foot, OR 19.63; 95 % CI 3.43-112.5), hypertension (lower risk, OR 0.3; 95 % CI 0.14-0.63), region of origin (South/Southeast, OR 2.2; 95 % CI 1.1-4.42), previous history of ulcer (OR 9.66; 95 % CI 4.67-19.98) and altered vibratory sensation (OR 3.46; 95 % CI 1.64-7.33). There was no association between either outcome and ethnicity. Ulcer and amputation rates were high. Age at presentation was low and patients with ulcer presented a higher prevalence of neuropathy compared to ischemic foot at risk. Ischemic disease was more associated with amputations. Ethnical differences were not of great importance in a miscegenated population.
