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Chao, Chih-Hua; Wu, Yuan-Jhong; Huang, Tzu-Yin; Tai, Chi-Jen; Chen, Yi-Ju; Huang, Chiung-Yao; Lin, Chi-Chien; Dai, Chang-Feng; Huang, Hui-Chi; Sheu, Jyh-Horng
Molecules (Basel, Switzerland), 01/2023, Volume: 28, Issue: 2Journal Article
The present chemical investigation on the organic extract of the soft coral has contributed to the isolation of four new cembranoids: 16 - and 16 -hydroperoxyisosarcophytoxides ( and ), 16 - and 16 -methoxyisosarcophytoxides ( and ), and a known cembranoid, lobocrasol ( ). The structures of all isolates were elucidated by detailed spectroscopic analysis. Their structures were characterized by a 2,5-dihydrofuran moiety, of which the relative configuration was determined by DU8-based calculation for long-range coupling constants ( ). The cytotoxicity and immunosuppressive activities of all isolates were evaluated in this study.
