E-resources
Peer reviewed
Open access
-
Uraki, Ryuta; Iida, Shun; Halfmann, Peter J; Yamayoshi, Seiya; Hirata, Yuichiro; Iwatsuki-Horimoto, Kiyoko; Kiso, Maki; Ito, Mutsumi; Furusawa, Yuri; Ueki, Hiroshi; Sakai-Tagawa, Yuko; Kuroda, Makoto; Maemura, Tadashi; Kim, Taksoo; Mine, Sohtaro; Iwamoto, Noriko; Li, Rong; Liu, Yanan; Larson, Deanna; Fukushi, Shuetsu; Watanabe, Shinji; Maeda, Ken; Wang, Zhongde; Ohmagari, Norio; Theiler, James; Fischer, Will; Korber, Bette; Imai, Masaki; Suzuki, Tadaki; Kawaoka, Yoshihiro
Nature communications, 03/2023, Volume: 14, Issue: 1Journal Article
The prevalence of the Omicron subvariant BA.2.75 rapidly increased in India and Nepal during the summer of 2022, and spread globally. However, the virological features of BA.2.75 are largely unknown. Here, we evaluated the replicative ability and pathogenicity of BA.2.75 clinical isolates in Syrian hamsters. Although we found no substantial differences in weight change among hamsters infected with BA.2, BA.5, or BA.2.75, the replicative ability of BA.2.75 in the lungs is higher than that of BA.2 and BA.5. Of note, BA.2.75 causes focal viral pneumonia in hamsters, characterized by patchy inflammation interspersed in alveolar regions, which is not observed in BA.5-infected hamsters. Moreover, in competition assays, BA.2.75 replicates better than BA.5 in the lungs of hamsters. These results suggest that BA.2.75 can cause more severe respiratory disease than BA.5 and BA.2 in a hamster model and should be closely monitored.
Author
![loading ... loading ...](themes/default/img/ajax-loading.gif)
Shelf entry
Permalink
- URL:
Impact factor
Access to the JCR database is permitted only to users from Slovenia. Your current IP address is not on the list of IP addresses with access permission, and authentication with the relevant AAI accout is required.
Year | Impact factor | Edition | Category | Classification | ||||
---|---|---|---|---|---|---|---|---|
JCR | SNIP | JCR | SNIP | JCR | SNIP | JCR | SNIP |
Select the library membership card:
If the library membership card is not in the list,
add a new one.
DRS, in which the journal is indexed
Database name | Field | Year |
---|
Links to authors' personal bibliographies | Links to information on researchers in the SICRIS system |
---|
Source: Personal bibliographies
and: SICRIS
The material is available in full text. If you wish to order the material anyway, click the Continue button.