E-resources
Peer reviewed
Open access
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Ben Hamadi, Naoufel; Guesmi, Ahlem
Molecules (Basel, Switzerland), 04/2022, Volume: 27, Issue: 8Journal Article
The synthesis of new insecticidal -dimethyspiro-cyclopropanes derived from pyrrolidine-2,3-dione have been described, and their biological effect against different insect species has been evaluated. The presented results demonstrate the excellent insecticidal activity of cyclopropane against and . Cyclopropane showed the quickest knockdown and the best killing against and compared to -chrysanthemic acid and pyrethrin. The biological results of the high insecticidal activity were confirmed by the results of docking. This is evident in the binding affinity obtained for cyclopropane , indicating good binding with an important active amino acid residue of the 5FT3 protein.
