E-resources
-
Yu, Jingyou; Tostanoski, Lisa H; Mercado, Noe B; McMahan, Katherine; Liu, Jinyan; Jacob-Dolan, Catherine; Chandrashekar, Abishek; Atyeo, Caroline; Martinez, David R; Anioke, Tochi; Bondzie, Esther A; Chang, Aiquan; Gardner, Sarah; Giffin, Victoria M; Hope, David L; Nampanya, Felix; Nkolola, Joseph; Patel, Shivani; Sanborn, Owen; Sellers, Daniel; Wan, Huahua; Hayes, Tammy; Bauer, Katherine; Pessaint, Laurent; Valentin, Daniel; Flinchbaugh, Zack; Brown, Renita; Cook, Anthony; Bueno-Wilkerson, Deandre; Teow, Elyse; Andersen, Hanne; Lewis, Mark G; Martinot, Amanda J; Baric, Ralph S; Alter, Galit; Wegmann, Frank; Zahn, Roland; Schuitemaker, Hanneke; Barouch, Dan H
Nature (London), 08/2021, Volume: 596, Issue: 7872Journal Article
The emergence of SARS-CoV-2 variants that partially evade neutralizing antibodies poses a threat to the efficacy of current COVID-19 vaccines . The Ad26.COV2.S vaccine expresses a stabilized spike protein from the WA1/2020 strain of SARS-CoV-2, and has recently demonstrated protective efficacy against symptomatic COVID-19 in humans in several geographical regions-including in South Africa, where 95% of sequenced viruses in cases of COVID-19 were the B.1.351 variant . Here we show that Ad26.COV2.S elicits humoral and cellular immune responses that cross-react with the B.1.351 variant and protects against B.1.351 challenge in rhesus macaques. Ad26.COV2.S induced lower binding and neutralizing antibodies against B.1.351 as compared to WA1/2020, but elicited comparable CD8 and CD4 T cell responses against the WA1/2020, B.1.351, B.1.1.7, P.1 and CAL.20C variants. B.1.351 infection of control rhesus macaques resulted in higher levels of virus replication in bronchoalveolar lavage and nasal swabs than did WA1/2020 infection. Ad26.COV2.S provided robust protection against both WA1/2020 and B.1.351, although we observed higher levels of virus in vaccinated macaques after B.1.351 challenge. These data demonstrate that Ad26.COV2.S provided robust protection against B.1.351 challenge in rhesus macaques. Our findings have important implications for vaccine control of SARS-CoV-2 variants of concern.
Author
![loading ... loading ...](themes/default/img/ajax-loading.gif)
Shelf entry
Permalink
- URL:
Impact factor
Access to the JCR database is permitted only to users from Slovenia. Your current IP address is not on the list of IP addresses with access permission, and authentication with the relevant AAI accout is required.
Year | Impact factor | Edition | Category | Classification | ||||
---|---|---|---|---|---|---|---|---|
JCR | SNIP | JCR | SNIP | JCR | SNIP | JCR | SNIP |
Select the library membership card:
If the library membership card is not in the list,
add a new one.
DRS, in which the journal is indexed
Database name | Field | Year |
---|
Links to authors' personal bibliographies | Links to information on researchers in the SICRIS system |
---|
Source: Personal bibliographies
and: SICRIS
The material is available in full text. If you wish to order the material anyway, click the Continue button.