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Muñoz-Fontela, César; Dowling, William E; Funnell, Simon G P; Gsell, Pierre-S; Riveros-Balta, A Ximena; Albrecht, Randy A; Andersen, Hanne; Baric, Ralph S; Carroll, Miles W; Cavaleri, Marco; Qin, Chuan; Crozier, Ian; Dallmeier, Kai; de Waal, Leon; de Wit, Emmie; Delang, Leen; Dohm, Erik; Duprex, W Paul; Falzarano, Darryl; Finch, Courtney L; Frieman, Matthew B; Graham, Barney S; Gralinski, Lisa E; Guilfoyle, Kate; Haagmans, Bart L; Hamilton, Geraldine A; Hartman, Amy L; Herfst, Sander; Kaptein, Suzanne J F; Klimstra, William B; Knezevic, Ivana; Krause, Philip R; Kuhn, Jens H; Le Grand, Roger; Lewis, Mark G; Liu, Wen-Chun; Maisonnasse, Pauline; McElroy, Anita K; Munster, Vincent; Oreshkova, Nadia; Rasmussen, Angela L; Rocha-Pereira, Joana; Rockx, Barry; Rodríguez, Estefanía; Rogers, Thomas F; Salguero, Francisco J; Schotsaert, Michael; Stittelaar, Koert J; Thibaut, Hendrik Jan; Tseng, Chien-Te; Vergara-Alert, Júlia; Beer, Martin; Brasel, Trevor; Chan, Jasper F W; García-Sastre, Adolfo; Neyts, Johan; Perlman, Stanley; Reed, Douglas S; Richt, Juergen A; Roy, Chad J; Segalés, Joaquim; Vasan, Seshadri S; Henao-Restrepo, Ana María; Barouch, Dan H
Nature, 10/2020, Volume: 586, Issue: 7830Journal Article
Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is the aetiological agent of coronavirus disease 2019 (COVID-19), an emerging respiratory infection caused by the introduction of a novel coronavirus into humans late in 2019 (first detected in Hubei province, China). As of 18 September 2020, SARS-CoV-2 has spread to 215 countries, has infected more than 30 million people and has caused more than 950,000 deaths. As humans do not have pre-existing immunity to SARS-CoV-2, there is an urgent need to develop therapeutic agents and vaccines to mitigate the current pandemic and to prevent the re-emergence of COVID-19. In February 2020, the World Health Organization (WHO) assembled an international panel to develop animal models for COVID-19 to accelerate the testing of vaccines and therapeutic agents. Here we summarize the findings to date and provides relevant information for preclinical testing of vaccine candidates and therapeutic agents for COVID-19.
