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Li, Haoxiang; He, Zhuobin; Shen, Qianhui; Fan, Weifeng; Tan, Guoying; Zou, Yuansheng; Mei, Quanxi; Qian, Zhengming
Molecules (Basel, Switzerland), 10/2021, Volume: 26, Issue: 20Journal Article
Polygoni Vivipari Rhizoma (PVR), the dried root of , has been used as herbal medicine in China for a long time. In the present study, a new method based on multi-step matrix solid-phase dispersion (MSPD), ultrafiltration and high performance liquid chromatography (HPLC) for screening alpha-glucosidase inhibitors (AGIs) from PVR was proposed. First, three different PVR extractions were prepared by multi-step MSPD with 15% methanol, 60% methanol and 100% methanol. Second, the alpha-glucosidase inhibition tests for the three extracts were carried out, and the 60% methanol extraction showed the best activity. Then, the AGIs screening experiment was performed with ultrafiltration and HPLC analysis using the 60% methanol extraction. Seven binding components (quercetin-3- -vicianoside, quercetin 3- -neohesperidoside, rutin, hyperoside, quercetin 3- -glucuronide, luteolin-7- -neohesperidoside, kaempferol 3-glucuronide) were found. These seven components were further validated as the AGIs by molecular docking analysis. The developed method was a rapid and efficient tool for screening AGIs from PVR, which provided scientific data for the bioactive components study of PVR.
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