Unutarstanični signalni putevi u karcinogenezi kolorektalnog tumora

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Unutarstanični signalni putevi u karcinogenezi kolorektalnog tumora

Badžek, Saša; Lesko Kelović, Vesna; Pleština, Stjepko; Prejac, Juraj; Majerović, Mate; Augustin, Goran

Acta chirurgica Croatica, 03/2012, Volume: 9, Issue: 1

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Karcinom kolorektalnog tumora jedna je od najčešćih i najsmrtonosnijih malignih bolesti, s oko 500 000 novootkrivenih sluča jeva diljem svijeta godišnje. Zlatni standard sekundarne prevencije je kolonoskopija s polipekto mijom, koja smanjuje učestalost raka crijeva za 30-40% u rizičnoj populaciji. Prvotni pokušaji primarne prevencije karcinoma crijeva selektivnim nesteroidnim protuupal nim lijekovima pokolebani su njihovom neočekivanom toksičnošću. Boljim upoznavanjem unutarstaničnih signalnih puteva karcinogeneze, čiji pregled donosimo u ovom članku, spoznaju se nove mogućnosti njihovog selektivnog isključivanja, a samim time i sprečavanja nastanka karcinoma.

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