The entanglement in the neutral kaon pairs produced at the DAΦNE ϕ-factory is a unique tool to test discrete symmetries and quantum coherence at the utmost sensitivity, in particular strongly motivating the experimental searches of possible CPT violating effects, which would unambiguously signal New Physics. KLOE and KLOE-2 data sets with about 2.4×1010 ϕ-meson produced represent the largest sample ever collected at the ϕ-meson peak. The lepton charge asymmetry measured in KS semileptonic decays with 1.7 fb−1 of KLOE data, improving the statistical uncertainty of present result by about a factor two, has been presented together with the test of CPT in transitions in ϕ → KSKL → π±e∓ν, 3π0 and KSKL → π+π−, π±e∓ν decays.