Highly toxic organophosphorus compounds (OPs) were originally developed for warfare or as agricultural pesticides. Today, OPs represent a serious threat to military personnel and civilians. This study investigates the in vivo decontamination of male Wistar rats percutaneously exposed to paraoxon and two potent nerve agents - soman (GD) and VX. Four commercial detergents were tested as decontaminants - Neodekont , Argos , Dermogel , and FloraFree . Decontamination performed 2 min after exposure resulted in a higher survival rate in comparison with non-decontaminated controls. The decontamination effectiveness was expressed as protective ratio (PR, median lethal dose of agent in decontaminated animals divided by the median lethal dose of agent in untreated animals). The highest decontamination effectiveness was consistently achieved with Argos (PR=2.3 to 64.8), followed by Dermogel (PR=2.4 to 46.1). Neodekont and FloraFree provided the lowest decontamination effectiveness, equivalent to distilled water (PR=1.0 to 43.2). Visokotoksični organofosforni spojevi (krat. OP) prvotno su se proizvodili za ratovanje i uporabi u poljoprivredi kao pesticidi. Danas su nepobitno iznimna prijetnja vojnom osoblju i civilima. Ova studija istražuje in vivo dekontaminaciju muških štakora Wistar perkutano izloženih paraoksonu i dvama snažnim nervnim agensima - somanu (GD) i VX-u. Četiri komercijalna deterdženta ispitana su kao sredstva dekontaminacije - Neodekont, Argos, Dermogel i FloraFree. Dekontaminacija dvije minute nakon izlaganja rezultirala je višom stopom preživljavanja u usporedbi s nedekontaminiranom kontrolnom skupinom. Učinkovitost dekontaminacije izražena je kao zaštitni omjer (PR, medijan smrtonosne doze agenta u dekontaminiranih životinja podijeljen s medijanom smrtonosne doze agenta u nedekontaminiranih životinja). Najveća konzistentna učinkovitost postignuta je Argosom (PR=2.3 do 64.8) i Dermogelom (PR=2.4 do 46.1). Deterdženti Neodekont i FloraFree bili su najmanje učinkoviti i imali jednak učinak kao destilirana voda (PR=1.0 do 43.2).