Three distinct motifs within the C-terminus of acid-sensing ion channel 1a regulate its surface trafficking

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Three distinct motifs within the C-terminus of acid-sensing ion channel 1a regulate its surface trafficking

Jing, L; Chu, X.-P; Zha, X.-M

Neuroscience, 09/2013, Volume: 247

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Highlights • We performed a systematic screening of C-terminal motifs regulating ASIC1a trafficking. • Mutating two K/R rich motifs reduces surface trafficking and acid-activated current of ASIC1a. • Mutating the PDZ binding motif of ASIC1a has the opposite effect. • The mutants alter N -glycosylation, which may explain the changes in trafficking and channel properties of ASIC1a.

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Jing, L | Chu, X.-P | Zha, X.-M

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