Background: Tobacco especially cigarette, smoking is a major risk factor for cardiovascular disease (CVD), such as stroke and ischemic heart disease. According to the World Health Organization that 10% of all deaths due to CVD are attributed to smoking. Basic ingredients of tobacco, causes an increase the risk of oxidative stress, impair the vascular endothelial function and activate the sympathetic nervous system. These associated with significantly higher serum concentrations of total cholesterol, triglycerides and lower levels of HDL. Smoking may leads to impairment in physical fitness. We have observed the effects of smoking on cardiorespiratory fitness stratified by body mass index (BMI) in the college students and also hypothesized that smoking may lead to decreased physical fitness despite a good level of physical activity in daily life. Objectives: The main objective of this study was to assess the effect of smoking on cardio-respiratory fitness and physical performances of an individual. Methods: This was a cross sectional study, 50 smoker (Group-I), 50 non-smoker (Group-II) college students were used. Each subject’s age, smoking habits, the duration of smoking, health conditions were recorded. Anthropometrics, body composition, BMI, BP, PFT and PFI testing were assessed. Results: Result shows that 32 people are smoking <10 cigarettes daily but only 2 persons smoke ≥20 cigarettes daily. SBP and DBP were more in smoker’s College students. The respiratory rate of smoker’s college students is higher than that of non-smoker. Smokers strength of the respiratory muscle is less than non-smoker as a result they have reduced vital capacity. Conclusion: Smoking increases the risk of virtually all CVD parameters, including that of the newly identified risk of paroxysmal tachycardia.