At present, it is the most important period to achieve the dual carbon goal and China 's economic transformation. The Chengdu-Chongqing twin-city economic circle plan is an important national policy proposed to promote the high-quality economic development of western China. However, due to the influence of geographical location, the frequent natural disasters in the economic circle of Chengdu and Chongqing have become a problem that cannot be ignored in the process of economic development. Many studies have discussed the relationship between natural hazards and economic development or between resource utilization and economic development in megacities, but little attention has been paid to the relationship between the three in intra-city development. This paper takes three cities in Chengdu-Chongqing Economic Circle as examples. The environment-resource-economy related evaluation factors are selected from various aspects such as hazard, vulnerability, susceptibility and disaster prevention and mitigation capacity. And establish a suitable evaluation system for disaster risk assessment. At the same time, our study demonstrates the uniqueness of the study by taking different disasters in different regions as entry points. The results of the study show that, although the natural hazards that often occur in cities are not the same, there is a strong repetition of the characteristics that characterize the disaster (extreme) high risk areas. The occurrence of natural disasters has a significant impact on infrastructure, human safety and economic development and recovery in areas of high human activity. Moreover, the progress of energy conservation and emission reduction varies greatly among cities due to factors such as geographic location and natural resources, and there are still cases of uneven development, lagging industrial innovation and high dependence on energy for economic development. These results can help mega-city clusters to provide opinions on economic development, energy saving and emission reduction, disaster prevention and control, and other aspects. Provide reference for the government to rationally plan the economic and industrial layout in the future. Remind the relevant departments in high-risk areas that they should enrich emergency response measures and strengthen hazard screening. Improve disaster prevention and control capacity to reduce losses and promote the coordinated development of environment-resources-economy. This is of great significance and practical value for better understanding of the environment, utilizing natural resources, avoiding and mitigating losses from natural disasters, and realizing the dual-carbon goal. •Analysis and research from different impact factors, evaluation of different types of disasters in different cities.•The high-risk areas of disasters in each city have the same characteristics.•The occurrence of natural disasters will inevitably have a great impact on economic development and recovery.•Small cities have limited resources and focus on the development of pillar industries, affecting planning and policies.•Cities still suffer from uneven development and lagging industrial innovation.