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  • Formation of new chromosomes as a virulence mechanism in yeast Candida glabrata
    Poláková, Silvia ...
    In eukaryotes, the number and rough organization of chromosomes is well preserved within isolates of the same species. Novel chromosomes and loss of chromosomes are infrequent and usually associated ... with pathological events. Here, we analyzed 40 pathogenic isolates of a haploid and asexual yeast, Candida glabrata, for their genome structure and stability. This organism has recently become the second most prevalent yeast pathogen in humans. Although the gene sequences were well conserved among different strains, their chromosome structures differed drastically. The most frequent events reshapingchromosomes were translocations of chromosomal arms. However, also larger segmental duplications were frequent and occasionally we observed novelchromosomes. Apparently, this yeast can generate a new chromosome by duplication of chromosome segments carrying a centromere and subsequently adding novel telomeric ends. We show that the observed genome plasticity is connected with antifungal drug resistance and it is likely an advantage in thehuman body, where environmental conditions fluctuate a lot.
    Vir: Proceedings of the National Academy of Sciences of the United States of America. - ISSN 0027-8424 (Vol. 106, no. 8, 2009, str. 2688-2693)
    Vrsta gradiva - članek, sestavni del
    Leto - 2009
    Jezik - angleški
    COBISS.SI-ID - 25480153
    DOI

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