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  • The effect of triple therapy on the mortality of catastrophic anti-phospholipid syndrome patients
    Rodríguez-Pintó, Ignasi ...
    Objectives: The objective of this study was to assess the effect that triple therapy (anticoagulation plus CS plus plasma exchange and/or IVIGs) has on the mortality risk of patients with ... catastrophic APS (CAPS) included in the CAPS Registry. Methods: Patients from the CAPS Registry were grouped based on their treatments: triple therapy; drugs included in the triple therapy but in different combinations; and none of the treatments included in the triple therapy. The primary endpoint was all-cause mortality. Multivariate logistic regression models were used to compare mortality risk between groups. Results: The CAPS Registry cohort included 525 episodes of CAPS accounting for 502 patients. After excluding 54 episodes (10.3%), a total of 471 patients with CAPS were included [mean (s.d.) age 38.5 years (17); 68.2% female; primary APS patients 62%]. Overall, 174 (36.9%) patients died. Triple therapy was prescribed in 189 episodes (40.1%), other combinations in 270 (57.3%) and none of those treatments in 12 episodes (2.5%); the mortality rate in the three groups was 28.6, 41.1 and 75%, respectively. Triple therapy was positively associated with a higher chance of survival when compared with non-treatment [adjusted odds ratio (OR) = 9.7, 95% CI: 2.3, 40.6] or treatment with other combinations of drugs included in the triple therapy (adjusted OR = 1.7, 95% CI: 1.2, 2.6). No statistical differences were found between patients that received triple therapy with plasma exchange or IVIGs (P = 0.92). Conclusion: Triple therapy is independently associated with a higher survival rate among patients with CAPS.
    Vir: Rheumatology. - ISSN 1462-0324 (Vol. 57, iss. 7, Jul. 2018, str. 1264-1270)
    Vrsta gradiva - članek, sestavni del
    Leto - 2018
    Jezik - angleški
    COBISS.SI-ID - 29243139

    Povezava(-e):

    https://academic.oup.com/rheumatology/article/57/7/1264/4967718
    DOI

vir: Rheumatology. - ISSN 1462-0324 (Vol. 57, iss. 7, Jul. 2018, str. 1264-1270)
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