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  • Molekularna epidemiologija okužbe s HIV v Sloveniji = Molecular epidemiology of HIV infection in Slovenia
    Lunar, Maja M., 1982- ...
    BACKGROUND. The aim of the present study was to describe the characteristics of HIV epidemic in Slovenia and further explore the evolutionary history of the subtype B epidemic. METHODS. A total of ... 367 partial HIV-1 pol sequences from Slovenian patients were included, representing 57 % of all patients diagnosed in Slovenia by the end of 2013. We further studied 223 sequences in the analysis of subtype B phylodynamics. RESULTS. Subtype B was the most prevalent subtype, determined in 313 out of 367 (85.3 %) patients. Subtype A and CRF02_AG were most common non-B subtypes, detected in 6.5 % and 2.5 % of patients. Analysis of HIV-1 subtype B transmission chains revealed 8 major clusters (n % 10 patients), 1 group of 4 patients, 2 trios and 12 transmission pairs, thus leaving only 43 (19.3 %) of Slovenian patients without a local epidemiological link. Bayesian analysis (incorporating molecular clock) estimated several introductions of HIV-1 into Slovenia, with most recent common ancestor of the earliest Slovenian cluster dated to the year 1986. We observed a 10-times faster evolutionary rate of Slovenian sequences compared to rate previously described for pol region. CONCLUSIONS. The majority of Slovenian patients had a local transmission link, indicating a closed HIV community. The observed faster evolutionary rate and thus slower epidemic rate suggests that individuals with a long-lasting infection are the driving force of the epidemic.
    Vir: Okužbe spolovil in spolno prenosljive bolezni : [zbornik predavanj] (Letn. 53, supl. 6, nov. 2014, str. 147-152)
    Vrsta gradiva - prispevek na konferenci ; neleposlovje za odrasle
    Leto - 2014
    Jezik - slovenski
    COBISS.SI-ID - 31959257

    Povezava(-e):

    http://www.imi.si/strokovna-zdruzenja/strokovna-srecanja/datoteke/20146BanicevidneviSpolnoprenosljive.pdf

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