VSE knjižnice (vzajemna bibliografsko-kataložna baza podatkov COBIB.SI)
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Meta-analysis and experimental validation identified FREM2 and SPRY1 as new glioblastoma marker candidates [Elektronski vir]Vidak, Marko ...Glioblastoma (GB) is the most aggressive brain malignancy. Although some potential glioblastoma biomarkers have already been identified, there is a lack of cell membrane-bound biomarkers capable of ... distinguishing brain tissue from glioblastoma and/or glioblastoma stem cells (GSC), which are responsible for the rapid post-operative tumor reoccurrence. In order to find new GB/GSC marker candidates that would be cell surface proteins (CSP), we have performed meta-analysis of genome-scale mRNA expression data from three data repositories (GEO, ArrayExpress and GLIOMASdb). The search yielded ten appropriate datasets, and three (GSE4290/GDS1962, GSE23806/GDS3885, and GLIOMASdb) were used for selection of new GB/GSC marker candidates, while the other seven (GSE4412/GDS1975, GSE4412/GDS1976, E-GEOD-52009, E-GEOD-68848, E-GEOD-16011, E-GEOD-4536, and E-GEOD-74571) were used for bioinformatic validation. The selection identified four new CSP-encoding candidate genes-CD276, FREM2, SPRY1, and SLC47A1-and the bioinformatic validation confirmed these findings. A review of the literature revealed that CD276 is not a novel candidate, while SLC47A1 had lower validation test scores than the other new candidates and was therefore not considered for experimental validation. This validation revealed that the expression of FREM2-but not SPRY1-is higher in glioblastoma cell lines when compared to non-malignant astrocytes. In addition, FREM2 gene and protein expression levels are higher in GB stem-like cell lines than in conventional glioblastoma cell lines. FREM2 is thus proposed as a novel GB biomarker and a putative biomarker of glioblastoma stem cells. Both FREM2 and SPRY1 are expressed on the surface of the GB cells, while SPRY1 alone was found overexpressed in the cytosol of non-malignant astrocytes.Vir: International journal of molecular sciences [Elektronski vir]. - ISSN 1422-0067 (Vol. 19, iss. 5, May 2018, str. 1-24)Vrsta gradiva - e-članek ; neleposlovje za odrasleLeto - 2018Jezik - angleškiCOBISS.SI-ID - 33752793
Avtor
Vidak, Marko |
Jovchevska, Ivana |
Šamec, Neja, 1983- |
Zottel, Alja |
Liović, Mirjana |
Rozman, Damjana, 1960- |
Džeroski, Sašo |
Juvan, Peter, računalničar |
Komel, Radovan
Teme
glioblastom |
23/5000 matične celice glioblastoma |
biomarkerji |
glioblastoma |
glioblastoma stem cells |
biomarkers
Vnos na polico
Trajna povezava
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Faktor vpliva
Dostop do baze podatkov JCR je dovoljen samo uporabnikom iz Slovenije. Vaš trenutni IP-naslov ni na seznamu dovoljenih za dostop, zato je potrebna avtentikacija z ustreznim računom AAI.
Leto | Faktor vpliva | Izdaja | Kategorija | Razvrstitev | ||||
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JCR | SNIP | JCR | SNIP | JCR | SNIP | JCR | SNIP |
Baze podatkov, v katerih je revija indeksirana
Ime baze podatkov | Področje | Leto |
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Povezave do osebnih bibliografij avtorjev | Povezave do podatkov o raziskovalcih v sistemu SICRIS |
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Vidak, Marko | 36368 |
Jovchevska, Ivana | 38279 |
Šamec, Neja, 1983- | 33735 |
Zottel, Alja | 39126 |
Liović, Mirjana | 14305 |
Rozman, Damjana, 1960- | 06013 |
Džeroski, Sašo | 11130 |
Juvan, Peter, računalničar | 21352 |
Komel, Radovan | 06135 |
Vir: Osebne bibliografije
in: SICRIS
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