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Peripheral impairments of oxidative metabolism after a 10-day bed rest are upstream of mitochondrial respiration [Elektronski vir]Zuccarelli, Lucrezia ...In order to identify peripheral biomarkers of impaired oxidative metabolism during exercise following a 10-day bed rest, 10 males performed an incremental exercise (to determine peak pulmonary V%O2 ... (V%O2p)) and moderate-intensity exercises, before (PRE) and after (POST) bed rest. Blood flow response was evaluated in the common femoral artery by Eco-Doppler during 1 min of passive leg movements (PLM). The intramuscular matching between O2 delivery and O2 utilization was evaluated by near-infrared spectroscopy (NIRS). Mitochondrial respiration was evaluated ex vivo by high-resolution respirometry in isolated muscle fibres, and in vivo by NIRS by the evaluation of skeletal muscle V%O2 (V%O2m) recovery kinetics. Resting V%O2m was estimated by NIRS. Peak V%O2p was lower in POST vs. PRE. The area under the blood flow vs. time curve during PLM was smaller (P = 0.03) in POST (274 % 233 mL) vs. PRE (427 % 291). An increased (P = 0.03) overshoot of muscle deoxygenation during a metabolic transition was identified in POST. Skeletal muscle citrate synthase activity was not different (P = 0.11) in POST (131 % 16 nmol min%1 mg%1) vs. PRE (138 % 19). Maximal ADP-stimulated mitochondrial respiration (66 % 18 pmol s%1 mg%1 (POST) vs. 72 % 14 (PRE), P = 0.41) was not affected by bed rest. Apparent Km for ADP sensitivity of mitochondrial respiration was reduced in POST vs. PRE (P = 0.04). The V%O2m recovery time constant was not different (P = 0.79) in POST (22 % 6 s) vs. PRE (22 % 6). Resting V%O2m was reduced by 25% in POST vs. PRE (P = 0.006). Microvascular-endothelial function was impaired following a 10-day bed rest, whereas mitochondrial mass and function (both in vivo and ex vivo) were unaffected or slightly enhanced.Vir: The journal of physiology [Elektronski vir]. - ISSN 1469-7793 (Vol. 599, iss. 21, 2021, str. 4813-4829)Vrsta gradiva - e-članek ; neleposlovje za odrasleLeto - 2021Jezik - angleškiCOBISS.SI-ID - 80230659
Avtor
Zuccarelli, Lucrezia |
Baldassarre, Giovanni |
Magnesa, Benedetta |
Degano, Cristina |
Comelli, Marina |
Gasparini, Mladen |
Manferdelli, Giorgio |
Šimunič, Boštjan |
Pišot, Rado |
Narici, Marco Vicenzo
Teme
bed rest |
microgravity |
mitochondrial respiration |
oxidative metabolism |
skeletal muscles |
bed rest |
microgravitacija |
celično dihanje |
presnova kisika |
skeletne mišice |
mišičnoskeletni sistem
Vnos na polico
Trajna povezava
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Povezave do osebnih bibliografij avtorjev | Povezave do podatkov o raziskovalcih v sistemu SICRIS |
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Zuccarelli, Lucrezia | |
Baldassarre, Giovanni | |
Magnesa, Benedetta | |
Degano, Cristina | |
Comelli, Marina | |
Gasparini, Mladen | 55075 |
Manferdelli, Giorgio | |
Šimunič, Boštjan | 21102 |
Pišot, Rado | 11612 |
Narici, Marco Vicenzo | 38863 |
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