-
Biological evaluation of Valeriana extracts from Argentina with potent cholinesterase inhibition for the treatment of neurodegenerative disorders and their comorbidities—The case of Valeriana carnosa Sm. (Caprifoliaceae) studied in mice [Elektronski vir]Marcucci, Carolina ...Alzheimer’s disease (AD) is a neurodegenerative disorder whose pathophysiology includes the abnormal accumulation of proteins (e.g., β-amyloid), oxidative stress, and alterations in neurotransmitter ... levels, mainly acetylcholine. Here we present a comparative study of the effect of extracts obtained from endemic Argentinian species of valerians, namely V. carnosa Sm., V. clarionifolia Phil. and V. macrorhiza Poepp. ex DC from Patagonia and V. ferax (Griseb.) Höck and V. effusa Griseb., on different AD-related biological targets. Of these anxiolytic, sedative and sleep-inducing valerians, V. carnosa proved the most promising and was assayed in vivo. All valerians inhibited acetylcholinesterase (IC50 between 1.08–12.69 mg/mL) and butyrylcholinesterase (IC50 between 0.0019–1.46 mg/mL). They also inhibited the aggregation of β-amyloid peptide, were able to chelate Fe2+ ions, and exhibited a direct relationship between antioxidant capacity and phenolic content. Moreover, V. carnosa was able to inhibit human monoamine oxidase A (IC50: 0.286 mg/mL (0.213–0.384)). A daily intake of aqueous V. carnosa extract by male Swiss mice (50 and 150 mg/kg/day) resulted in anxiolytic and antidepressant-like behavior and improved spatial memory. In addition, decreased AChE activity and oxidative stress markers were observed in treated mouse brains. Our studies contribute to the development of indigenous herbal medicines as therapeutic agents for AD.Vir: Pharmaceuticals [Elektronski vir]. - ISSN 1424-8247 (Vol. 16, no. 1, art. 129, 2023, 25 str.)Vrsta gradiva - e-članek ; neleposlovje za odrasleLeto - 2023Jezik - angleškiCOBISS.SI-ID - 137955843
Avtor
Marcucci, Carolina |
Rademacher, Marina |
Kamecki, Fabiola |
Pastore, Valentina |
Gerónimo Bach, Hernán |
Ricco, Rafael Alejandro |
Wagner, Marcelo Luis |
Knez, Damijan, farmacevt |
Gobec, Stanislav, 1970- |
Colettis, Natalia |
Marder, Mariel
Teme
Alzheimerjeva bolezen |
Zdravilne rastline |
Antioksidanti |
Antidepresivi |
acetilholinesteraza |
agregacija β-amiloida |
monoaminooksidaza |
spomin |
Alzheimer’s disease |
medicinal plant |
acetylcholinesterase |
antioxidant |
β-amyloid aggregation |
monoamine oxidase |
memory |
antidepressant
Avtor | Marcucci, Carolina ... |
Naslov | Biological evaluation of Valeriana extracts from Argentina with potent cholinesterase inhibition for the treatment of neurodegenerative disorders and their comorbidities—The case of Valeriana carnosa Sm. (Caprifoliaceae) studied in mice [Elektronski vir] |
Datum objave | 2023-01-16 |
COBISS.SI-ID | 137955843 |
Verzija objave v repozitoriju | Založnikova različica |
Licenca objave v repozitoriju | Creative Commons Priznanje avtorstva 4.0 Mednarodna |
Embargo | Takojšnja javna objava |
Projekti, iz katerih je bila financirana objava
Naziv | Akronim | Številka projekta | Financer |
---|---|---|---|
Razvoj multifunkcionalnih učinkovin za zdravljenje Alzheimerjeve bolezni | L1-8157-2017 |
Javna agencija za znanstvenoraziskovalno in inovacijsko dejavnost Republike Slovenije |
|
Kovalentni zaviralci: zaviranje monoamin oksidaze preko nekatalitskih aminokislinskih ostankov | Z1-1859-2019 |
Javna agencija za znanstvenoraziskovalno in inovacijsko dejavnost Republike Slovenije |
|
Farmacevtska kemija: načrtovanje, sinteza in vrednotenje učinkovin | P1-0208-2022 |
Javna agencija za znanstvenoraziskovalno in inovacijsko dejavnost Republike Slovenije |
Datoteke, ki spadajo k objavi
Povezava |
---|
https://www.mdpi.com/1424-8247/16/1/129 |
https://repozitorij.uni-lj.si/IzpisGradiva.php?id=143867 |
Vnos na polico
Trajna povezava
- URL:
Faktor vpliva
Dostop do baze podatkov JCR je dovoljen samo uporabnikom iz Slovenije. Vaš trenutni IP-naslov ni na seznamu dovoljenih za dostop, zato je potrebna avtentikacija z ustreznim računom AAI.
Leto | Faktor vpliva | Izdaja | Kategorija | Razvrstitev | ||||
---|---|---|---|---|---|---|---|---|
JCR | SNIP | JCR | SNIP | JCR | SNIP | JCR | SNIP |
Baze podatkov, v katerih je revija indeksirana
Ime baze podatkov | Področje | Leto |
---|
Povezave do osebnih bibliografij avtorjev | Povezave do podatkov o raziskovalcih v sistemu SICRIS |
---|---|
Marcucci, Carolina | |
Rademacher, Marina | |
Kamecki, Fabiola | |
Pastore, Valentina | |
Gerónimo Bach, Hernán | |
Ricco, Rafael Alejandro | |
Wagner, Marcelo Luis | |
Knez, Damijan, farmacevt | 36438 |
Gobec, Stanislav, 1970- | 15284 |
Colettis, Natalia | |
Marder, Mariel |
Izberite prevzemno mesto:
Prevzem gradiva po pošti
Obvestilo
Gesla v Splošnem geslovniku COBISS
Izbira mesta prevzema
Mesto prevzema | Status gradiva | Rezervacija |
---|
Prosimo, počakajte trenutek.