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Fakulteta za farmacijo, Ljubljana (FFALJ)
  • Dual antagonists of integrins
    Nadrah, Kristina ; Sollner Dolenc, Marija
    The roles of integrins in pathologies have been studied intensively and only partially explained.This has resulted in the development of several nanomolar antagonists to certain integrins. In most ... cases, the aim was to produce compounds which are highly selective towards specific integrins. This paradigmhas recently shifted a little. Targeting two or more integrins with one compound has become a very attractive concept, especially since it has become clear that several severe disorders, such as pathological angiogenesis,cannot be treated just with highly specific integrin antagonists.This review is aimed to elucidate some aspects regarding the design of drugs with dual activity towards integrins. Integrin structure and tissue distribution will first be described, in order to provide the basis fortheir functions in various pathologies which will follow. Inhibitors of several pairs of integrins will be described.
    Vir: Current medicinal chemistry. - ISSN 0929-8673 (Vol. 12, no. 12, 2005, str. 1449-1466)
    Vrsta gradiva - članek, sestavni del
    Leto - 2005
    Jezik - angleški
    COBISS.SI-ID - 1741681

vir: Current medicinal chemistry. - ISSN 0929-8673 (Vol. 12, no. 12, 2005, str. 1449-1466)

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