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  • Naše prve izkušnje s traneksamično kislino pri zdravljenju krvavitev pri dializnih bolnikih = Tranexamic acid in the treatment of bleeding in dialysis patients: our first experience
    Vujkovac, Bojan ; Lavre, Janez ; Šabovič, Mišo
    Background. In patients with end stage renal disease, in the program of chronic hemodialysis, the bleeding is a common and potentially fatal complication arising from multiple acquired defects in ... hemostasis. The abilityof tranexamic acid (TA), a potent antifibrinolytic agent, to stop serious bleeding in the dialysis patients was studied. Methods and results. During 57 months we treated 31 bleeding episodes (23 from upper gastrointestinal tract, 6 from lower gastrointestinal tract and 2 cerebral bleeding) in 16 dialysis patients. TA was used in the treatment of 6 episodes of serious bleeding from upper gastrointestinal, 4 episodes from lower gastrointestinal tract and two cases of cerebral bleeding. The dosage schedulefor TA was 20 mg/kg body weight (mg/ kg) intravenously followed by 10 or 20 mg/kg/48 hours orally for at least four weeks. No significant decrease in haemoglobin concentrations was observed in all treated cases of the upper gastrointestinal bleeding, while in the group of patients who did not receivedTA recurrent bleeding occurred in 4 patients (23.5%). Hemorrhages fromlower gastrointestinal tract (colonic angiodysplasia) were all successfully treated with TA, but bleeding reappeared few months after treatment. Two treated patients with cerebral hemorrhage were comatose (Glasgow Coma Scale 7 and 5). In the former case subdural and intracerebral hematomas resolved, whereas second patient died. Conclusions. Our first (nonrandomized) results suggest that TA could successfully stop the bleeding in dialysis patients. This remains to be confirmed in a further randomized study.
    Vir: Zdravniški vestnik : glasilo Slovenskega zdravniškega društva = Slovenian medical journal = journal of Slovenian Medical Association. - ISSN 1318-0347 (Letn. 69, št. 5, maj 2000, str. 345-348)
    Vrsta gradiva - članek, sestavni del
    Leto - 2000
    Jezik - slovenski
    COBISS.SI-ID - 11630553

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