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  • Trombotična trombocitopenična purpura po tiklopidinu = Thrombotic thrombocytopenic purpura associated with ticlopidine use
    Preložnik Zupan, Irena, medicina ; Zupan, Igor, 1961-
    Background. Thrombotic thrombocytopenic purpura (TTP) is rare and often fatal disorder characterized by thrombocytopenia, microangiopathis hemolytic anemia,neurological simptomes and signs and ... dysfunction. Ticlopidine is one ofseveral drugs that have been associated with this disorder. It is routinely used in Slovenia in patients undergoing percutaneous coronary intervention involving a stent and also in some other indications. The TTP incidence of 0.02% in ticlopidine-treated patients following coronary stenting is cosiderably higher than the estimated incidence of 0.0004% in the general population. Limiting ticlopidine therapy to 2 weeks after stenting does not prevent the development of TTP. It is essential to chesk blood cell count at least two weeks after initiating treatment with ticlopidine. Conclusions. Thisarticle presents a patient with ticlopidine associated TTP three weeks after coronary stenting. This clinical indications for ticlopidine use are expanding, and thus, serious adverse effect such as TTP are being encountered more frequently. Physicians and patients should be aware of this potentially fatal but treatable complication of ticlopidine therapy.
    Vir: Zdravniški vestnik : glasilo Slovenskega zdravniškega društva = Slovenian medical journal = journal of Slovenian Medical Association. - ISSN 1318-0347 (Letn. 69, št. 12, dec. 2000, str. 809-811)
    Vrsta gradiva - članek, sestavni del
    Leto - 2000
    Jezik - slovenski
    COBISS.SI-ID - 12596441

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