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  • Spremembe v mikrocirkulaciji pri sladkorni bolezni = Microcirculatory alterations in diabetes mellitus
    Fras, Zlatko
    Late complications in diabetes mainly reflect disorders in microcirculation. Diabetic microangiopathy is a generalised process, even though its clinical features of nephropathy, retinopathy, and ... neuropathy are better known. Muscles, the skin and heart are affected too. The most important factors in the development of microangiopathy are the duration of diabetes and proper metabolic control. The pathogenesis of this disorder is extremely complex and involves several factors. The development of new techniques for the assessmentof microcirculation has enabled a better insight into various stagesin the development of this disease and its key pathophysiological processes. Important data support the hemodynamic hypothesis with an increase in blood flow and pressure in small blood vessels during the initial stage of the disease. A consequence of endothelial damage is compensatory microvascularsclerosis, and a reduction of vasodilatory reserve and autoregulatory capacity. Disturbed functioning of endothelial cells, thickening of capillary membrane, atrophy of pericytes and vessel wall hypoxiacause increased transcapillary transport of various substances. Soon structural changes in capillaries occur which, together with simultaneously increased viscosity and hypercoagulability of blood, can cause capillary obstruction and tissue necrosis. The pattern of pathological changes in microcirculation probably varies in different forms of diabetes. In the insulin-independent form it could reflect the pre-diabetic phase of insulin resistance. The paper presents the framework of key pathophysiological processes, an attempt at describing the mutual connection of neuropathy and microangiopathy, includes a description of microcirculatory changes in diabetic foot, and some details of the importance of free radicals in the development of the disease.
    Vir: Medicinski razgledi. Supplement. - ISSN 0353-3484 (Letn. 40, supl. 3, apr. 2001, str. 55-71)
    Vrsta gradiva - članek, sestavni del
    Leto - 2001
    Jezik - slovenski
    COBISS.SI-ID - 14044889

vir: Medicinski razgledi. Supplement. - ISSN 0353-3484 (Letn. 40, supl. 3, apr. 2001, str. 55-71)

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