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  • The role of tumour suppressor genes in laryngeal squamous cell carcinoma : this work is written to honour the memory of prof. Vinko Kambič = Vloga tumor zavirajočih genov pri ploščatoceličnem karcinomu grla
    Nadal, Alfons ; Cardesa, Antonio
    We offer a general overview on tumour suppressor gene alterations identifiedin laryngeal squamous cell carcinoma. Addressing the retinoblastoma susceptibility gene inactivation by molecular genetic ... methods is a hard task due to its enormous size. However, loss of immunohistochemical expression of retinoblastoma protein is an infrequent event that we have observed in only one out of 37 cases (3%). p53 can be inactivated by a number of mechanisms. p53 protein overexpression is detected in a half of the cases, but p53 mutations are detected in only 34% of cases. Thus, a number of cases with p53 protein overexpression occur in the absence of detectable gene mutation. The implication of HPV in the development of these tumours seems, at most, marginal, p21waf1 is expressed with independence of the p53 gene status and isrelated to squamous cell differentiation. p16ink4a can be inactivated by mutation and allelic deletion or homozygous deletion (22% each), or promoter hypermethylation in less than 10% of cases.
    Vir: Zdravniški vestnik : glasilo Slovenskega zdravniškega društva = Slovenian medical journal = journal of Slovenian Medical Association. - ISSN 1318-0347 (Letn. 71, supl. 3, nov. 2002, str. III-25-III-27)
    Vrsta gradiva - članek, sestavni del
    Leto - 2002
    Jezik - angleški
    COBISS.SI-ID - 15695321

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