Monoklonska protitelesa proti TNF-[alfa] v diagnostiki in terapiji = Monoclonal antibodies against TNF-[alpha] in diagnostics and therapy
Čurin-Šerbec, Vladka
The importance of cytokines in connection with malignant diseases and autoimmune diseases such as rheumatoid arthritis (RA) is well established. On the other hand, the role and the importance of ...their natural inhibitors is notas clear yet. Tumor necrosis factor alpha (TNF-alpha) is a member of the cytokine family and is produced by stimulated mononuclear cells and certain fibroblasts. It appears in the form of a homotrimer molecule, which is biologically active. TNF-alpha has been discovered due to its ability to provoke tumor necrosis. It is cytotoxic and can in some cases activate proinflammatory factors. In addition to TNF-alpha, its two natural inhibitors,p55 (TNFRI) and p75 (TNFRII), are also produced. Both inhibitors can be found in human sera and urine, in the soluble form. Serum concentrations of these proteins can be determined using enzyme-linked immunosorbent assay (ELISA), based on monoclonal antibodies (MAb) against TNF-alpha and its soluble receptors in order to establish their diagnostic and/or prognostic value. Additionally, humanization of MAbs against TNF-alpha has led to successful treatment of some diseases, especially RA.
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