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  • Paraneoplastične retinopatije = Paraneoplastic retinopathies
    Hawlina, Marko ...
    Background. Two types of retinopathy are known to be associated with patients with malignancies: cancer associated retinopathy-CAR and cutaneus melanoma associated retinopathy-MAR. Autoantibodies ... against recoverin or against alfa-enolase have been described in CAR, and autoatibodies against ON-bipolar cells are formed in MAR. An outline of the pathogenetic mechanisms and an example of each cases disorder presented. Case reports. In both patients, the following were performed: complete clinical examination, visual acuity, visualfields, fluorescein angiography and electroretinography. The first patient was a 78 year-old man with epidermoid carcinoma of the the lung and metastases of liver and kidney suffered rapidly progressive bilateral visual loss. He suffered complete loss of visual (amaurosis with Antons syndrome). Retinal examination showed severe arterial narrowing with lipid plaques and age-related pigmentary changes. The ERG was nondetectable, and the diagnosis was CAR. The second patient was a 62 years old man who presented with acute onset of bilateral night blindness, photopsia and shimmering four years after excision of a cutaneus malignant melanoma. Visual acuity was 0.5 in the right eye and 0.8 in the left eye. The visual fields showed constriction to 15 degrees in both eyes on Goldmann perimetry. The retinal examination was normal. ERG maximal response was electronegative, with normal a-wave amplitudeand reduced b-wave. ON-OFF ERG showed loss of ON-response B-wave and normal OFF-response d-wave, typical for MAR. Conclusions. CAR and MAR are rareparaneoplastic sindromes, that are characterised by rapid onset of acquired bilateral visual loss and night blindness. (Abstract truncated at 2000 characters)
    Vir: Zdravniški vestnik : glasilo Slovenskega zdravniškega društva = Slovenian medical journal = journal of Slovenian Medical Association. - ISSN 1318-0347 (Letn. 74, št. 10, okt. 2005, str. 643-647)
    Vrsta gradiva - članek, sestavni del
    Leto - 2005
    Jezik - slovenski
    COBISS.SI-ID - 20411353

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    Digitalna knjižnica Slovenije - dLib.si

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