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  • Stanje obzobnih tkiv pri pacientih z revmatoidnim artritisom = Periodontal status in patients with rheumatoid arthritis
    Mikuž, Ani ; Rozman, Blaž, 1944- ; Skalerič, Uroš, 1945-2023
    Backgound: Rheumatoid arthritis (RA) and periodontitis (PD) have remarkably similar pathobiology and biochemical processes of tissue destruction. The aim of this study was to investigate the size of ... infected periodontal wounds and the salivary and serum levels of inflammatory mediators and cytokines in patients wih RA. Subjects and methods: Thirty-five patients with RA (30 females, 5 males) were included in our study. Data on erythrocyte sedimentation rate (ESR), C-reactive protein (CRP), rheumatoid factor (RF) andmedication were obtained from the patients' medical records. Interleukin 6 (IL6), tumour necrosis factor alpha (TNF-alpha) and highly sensitive CRP (hs-CRP) were measured in samples of serum and saliva. The size of infected periodontal wounds was determined by measuring probing depths and bleeding on probing. The number of missing teeth and the presence of clinical attachment loss were recorded. Results: Statistical analysis showed significant differences in (1) the size of deep periodontal wounds between patients with RA lasting up to 10 years and those with longer disease duration (0.43 t 0.37 cm2 vs. 0.21 t 0.15 mm2, p= 0.046), (2) the serum levels of TNF-alpha between patients with CRP values below 5mg/L and those with higher CRP values (6.54 2.40 ng/L vs. 11.59 8.45 ng/L, p= 0.03), and in (3) the serum levels of hs-CRP between patients with ESR below 20 mm/h and those with higher ESR values (4.05 4.21 mg/L vs. 18.71 18.85 mg/L, p=0.036). The patients had a higher average number of missing teeth than a control group of randomly selected healthy subjects of equal age (17). Conclusions: The study failed to confirm our hypothesis that the size of periodontal wounds influences the level of inflammatory mediators in the serum and saliva of patients with RA.
    Vir: Zobozdravstveni vestnik. - ISSN 0044-4928 (Letn. 61, št. 2/3, 2006, str. 55-62)
    Vrsta gradiva - članek, sestavni del
    Leto - 2006
    Jezik - slovenski
    COBISS.SI-ID - 22104025

vir: Zobozdravstveni vestnik. - ISSN 0044-4928 (Letn. 61, št. 2/3, 2006, str. 55-62)

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