-
Cytokine concentrations in basal cell carcinomas of different histological types and localizationElamin, Issa ...Background: Basal cell carcinoma (BCC) is the most common malignant skin tumor. Cytokines as major mediators of the immune system have been shown to play an important role in biology of the neoplasm ... with the general predomination of Th2 cytokines, whereas IFN-gamma and other Th1 cytokines are prevalent in spontaneously regressing tumors. Objective: We were interested incomparing cytokine levels in BCC and cutaneous squamous cell tumors with BCCof different localization and histological subtypes. Material and methods: Explants from freshly excised BCC from 18 patients, and cutaneous squamous cell tumors (solar keratoses and Bowenćs disease) from 9 patients were cultivated for 24 h. Cytokine (IL-2, IFN-gamma, IL-4, IL-5, IL-6, IL-8, IL-10,IL-12, TNFalpha, IL-1beta) concentrations in culture supernatants were determined by a sandwich immunoassay. Results: Tissue explants of BCC contained significantly higher concentrations of IL-1beta, IL-4, IL-5, and IL-6 compared to those of squamous cell tumors. Higher levels of TNF-alpha (p = 0.042), IL-4 (p = 0.028), and IL-5 (p = 0.012) were found in tumors localized to the head and neck compared to those on the trunk or extremities. Interleukin-6 concentrations were higher in aggressive BCC variants (infiltrative and micronodular), but the difference was not statistically significant (p = 0.068). Conclusions: Confirming the earlier findings that BCCis a tumor with a Th2 cytokine microenvironment, this study further shows that BCC situated on the head and neck produce even more of certain Th2 cytokines (IL-4 and IL-5) and TNF-alpha, a crucial immunosuppressive cytokine released upon UVB irradiation.Vir: Acta dermatovenerologica Alpina, Panonica et Adriatica. - ISSN 1318-4458 (Vol. 17, no. 2, jun. 2008, str. 55-59)Vrsta gradiva - članek, sestavni delLeto - 2008Jezik - angleškiCOBISS.SI-ID - 24540121
Avtor
Elamin, Issa |
Zečević, Radoš |
Vojvodić, Danilo |
Medenica, Ljiljana |
Pavlović, Miloš, 1966-
Teme
Skin Neoplasms |
Carcinoma, Basal Cell |
Cytokines |
Tumor Necrosis Factor |
Interleukin-4 |
Interleukin-5 |
Interleukin-2 |
Interleukin-6 |
Interleukin-8 |
Interleukin-10 |
Interleukin-12 |
Interleukin-1 |
Kožne novotvorbe |
Tumor nekrotizirajoči faktor |
Citokini |
Karcinom bazalnocelični |
Interlevkin-4 |
Interlevkin-6 |
Interlevkin-5 |
Interlevkin-8 |
Interlevkin-1 |
Interlevkin-2 |
Interlevkin-10 |
Interlevkin-12 |
dermatologija |
kožne novotvorbe |
rak (medicina) |
karcinom |
citokini |
histologija
vir: Acta dermatovenerologica Alpina, Panonica et Adriatica. - ISSN 1318-4458 (Vol. 17, no. 2, jun. 2008, str. 55-59)
Vnos na polico
Trajna povezava
- URL:
Faktor vpliva
Dostop do baze podatkov JCR je dovoljen samo uporabnikom iz Slovenije. Vaš trenutni IP-naslov ni na seznamu dovoljenih za dostop, zato je potrebna avtentikacija z ustreznim računom AAI.
Leto | Faktor vpliva | Izdaja | Kategorija | Razvrstitev | ||||
---|---|---|---|---|---|---|---|---|
JCR | SNIP | JCR | SNIP | JCR | SNIP | JCR | SNIP |
Baze podatkov, v katerih je revija indeksirana
Ime baze podatkov | Področje | Leto |
---|
Povezave do osebnih bibliografij avtorjev | Povezave do podatkov o raziskovalcih v sistemu SICRIS |
---|---|
Elamin, Issa | |
Zečević, Radoš | |
Vojvodić, Danilo | |
Medenica, Ljiljana | |
Pavlović, Miloš, 1966- | 30480 |
Izberite prevzemno mesto:
Prevzem gradiva po pošti
Obvestilo
Gesla v Splošnem geslovniku COBISS
Izbira mesta prevzema
Mesto prevzema | Status gradiva | Rezervacija |
---|
Prosimo, počakajte trenutek.
Naročanje gradiva za izposojo v čitalnice
Naročanje kopij člankov
Urnik dostave gradiva z oznako DS v signaturi