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  • Doseganje ciljne srčne frekvence, antiishemična učinkovitost in prenašanje zdravila ivabradin pri bolnikih s stabilno angino pektoris (raziskava OPTIMAL 60) = Target heart rate achievement, antiishemic drug efficacy and tolerability of ivabradin in patients with stable angina pectoris (OPTIMAL 60 study)
    Zupan, Igor, 1961- ; Lipar, Luka, dr. med.
    Heart rate reduction in patients with angina pectoris is basic method of treatment. Several different drugs are used, like beta-adrenergic receptor inhibitors, calcium channel blockers and selective ... If inhibitors. Beta-adrenergic receptor blockers are the drug of selection in patients with angina pectoris, but their use to achieve doses that were used in large dinical trials are in daily practice limited. Aims of the study "OPTlMAL60" were to evaluate the target heart rate in patients with angina pectoris, to prove the efficacy and safety of treatment with ivabradin and to identify options for further and more effective adjunctive therapy in patients with angina pectoris. In the study , "OPTIMAL60", reaching the target heart rate has been slightly lower than expected because the target heart rate reached only 35% of patients. This is probably due to a small number of patients that also received concomitant beta-adrenoceptor blockers because of possible side effects (asthma, diabetes, etc.). The second reason is probably in lower dosesof ivabradin (5 mg/12 hours) and not higher ones (7.5 mg/12 hours). Interestingly, we nevertheless found statistically significant correlation between heart rate and lowering the number of attacks of angina pectoris. Evenmore important figure is probably a subjective response to treatment, because in our study, more than 90% of patients were satisfied with treatment.Ischemic heart disease is the leading cause 'of morbidity and mortality in the developed world and therefore the search for new treatment approaches are essential to control this key pandemic of the 21st century. We hope that the study "OPTIMAL60" obtained relevant information that will help to improve treatment of patients with angina pectoris.
    Vir: Slovenska kardiologija : znanstveno strokovna revija za področje srčno-žilne medicine. - ISSN 1581-8543 (Letn. 7, št. 1, maj 2010, str. 36-40)
    Vrsta gradiva - članek, sestavni del
    Leto - 2010
    Jezik - slovenski
    COBISS.SI-ID - 27179737

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