-
Expression of NF-kB p65 phosphorylated at serine-536 in rectal cancer with or without preoperative radiotherapyLewander, Andreas ...Background. In the present study, we investigated NF-êB p65 phosphorylated at Serine-536 (phosphor-Ser536-p65) in rectal cancer and its relationship to preoperative radiotherapy (RT), ... clinicopathological variables and biological factors.Patients and methods. Expression of phosphor-Ser536-p65 was examined by using immunohistochemistry in 141primary rectal cancers, 149 normal mucosa specimens and 48 metastases in the lymph nodes, from rectal cancer patients who participated in a Swedish clinical trial of preoperative RT. Results. The expression of phosphor-Ser536-p65 in the cytoplasm increased from normal mucosa to primary tumour (p<0.0001, for both the group that did and the group that did not received RT). The expression did not further increase from primary tumour to metastasis in either group (p>0.05). Expression of phosphor-Ser536-p65 was positively related to, or tended to be related to, theexpression of tumour endothelium marker 1 (TEM1, p=0.02), FXYD-3 (p=0.001),phosphatase of regenerating liver (PRL, p=0.02), p73 (p=0.048) and meningioma associated protein (MAC30, p=0.05) in the group that received RT but there were no such relationships in the group that did not received RT (p>0.05). The expression of phosphor-Ser536-p65 was not related to clinicopathological factors including survival (p>0.05). Conclusions. The increased expression of phosphor-Ser536-p65 may be involved in rectal cancer development. After RT, phosphor-Ser536-p65 seems to be positively related to the biological factors, which associated with more malignant features of tumours. However, phosphor-Ser536-p65 was not directly related to the responseof RT based on recurrence and survival.Vir: Radiology and oncology. - ISSN 1318-2099 (Vol. 45, no. 4, 2011, str. 279-284, III)Vrsta gradiva - članek, sestavni delLeto - 2011Jezik - angleškiCOBISS.SI-ID - 29635289
Avtor
Lewander, Andreas |
Gao, Jinfang |
Adell, Gunnar |
Zhang, Hong, dr. med. |
Sun, Xiao-Feng
Teme
Rectal Neoplasms |
Radiotherapy |
Pathology |
Immunohistochemistry |
Lymphatic Metastasis |
Phosphoserine |
Nf-Kappa B |
Gene Expression |
Tumor Markers, Biological |
Rektalne novotvorbe |
Imunohistokemija |
NF-kapa B |
Fosfoserin |
Limfatična metastaza |
Tumorski označevalci biološki |
Gensko izražanje
Vnos na polico
Trajna povezava
- URL:
Faktor vpliva
Dostop do baze podatkov JCR je dovoljen samo uporabnikom iz Slovenije. Vaš trenutni IP-naslov ni na seznamu dovoljenih za dostop, zato je potrebna avtentikacija z ustreznim računom AAI.
Leto | Faktor vpliva | Izdaja | Kategorija | Razvrstitev | ||||
---|---|---|---|---|---|---|---|---|
JCR | SNIP | JCR | SNIP | JCR | SNIP | JCR | SNIP |
Baze podatkov, v katerih je revija indeksirana
Ime baze podatkov | Področje | Leto |
---|
Povezave do osebnih bibliografij avtorjev | Povezave do podatkov o raziskovalcih v sistemu SICRIS |
---|---|
Lewander, Andreas | |
Gao, Jinfang | |
Adell, Gunnar | |
Zhang, Hong, dr. med. | |
Sun, Xiao-Feng |
Izberite prevzemno mesto:
Prevzem gradiva po pošti
Obvestilo
Gesla v Splošnem geslovniku COBISS
Izbira mesta prevzema
Mesto prevzema | Status gradiva | Rezervacija |
---|
Prosimo, počakajte trenutek.
Naročanje gradiva za izposojo v čitalnice
Naročanje kopij člankov
Urnik dostave gradiva z oznako DS v signaturi