-
Effects of pregabalin on acute herpetic pain and postherpetic neuralgia incidenceKrčevski-Škvarč, Nevenka ; Kamenik, MirtBackground and objectives: Acute zoster pain usually disappears with regression of the rash but may be of significant intensity and prolonged duration leading to postherpetic neuralgia. We evaluated ... the effect of pregabalin on alleviation of acute zoster pain and onset of postherpetic neuralgia. Methods: The prospective randomized double-blind placebo-controlled study included 29 outpatients who had had acute zoster pain for a period of 7-14 days. Patients were treated for three weeks with 150-300 mg pregabalin daily or with a placebo. Pain was treated with naproxen, tramadol or oxycodone, as necessary. During the treatment we assessed pain, allodynia, hyperalgesia, severity of burning, prickling and tingling sensations, quality of sleep, physical activity, consumption of analgesics, manifestation of adverse events and postherpetic neuralgia. Results: There were no statistically significant differences with respect to patients' demographic data, dermatomal distribution and severity of rash, use of antiviral therapy or duration of acute zoster pain. Standard statistical analyses found no significant differences between the two treatment groups in intensity of pain, allodynia, hyperalgesia, burning, prickling and tingling sensations, consumption of analgesics, or the quality of sleep and physical activity; there was also no significant difference in development of postherpetic neuralgia. However, there were statistically significant differences between the groups in the occurrence of dizziness and somnolence in relation to pregabalin. Conclusion: The study did not prove any statistically significant effect of pregabalin in pain relief in patients with acute zoster pain or in the onset of postherpetic neuralgia in comparison with the placebo. The use of pregabalin was related to a statistically significant increase in the appearance of adverse effects.Vir: Wiener klinische Wochenschrift. Supplementum. - ISSN 0300-5178 (Jg. 122, suppl. 2, 2010, str. 49-53)Vrsta gradiva - članek, sestavni del ; neleposlovje za odrasleLeto - 2010Jezik - angleškiCOBISS.SI-ID - 3668031
Avtor
Krčevski-Škvarč, Nevenka |
Kamenik, Mirt
Teme
Herpes Zoster |
Herpes zoster |
Neuralgia, Postherpetic |
Nevralgija, postherpetična |
Pain |
therapy |
Bolečina |
Zdravljenje |
herpes zoster |
bolečina |
nevralgija |
pregabalin |
zdravljenje
vir: Wiener klinische Wochenschrift. Supplementum. - ISSN 0300-5178 (Jg. 122, suppl. 2, 2010, str. 49-53)
Vnos na polico
Trajna povezava
- URL:
Faktor vpliva
Dostop do baze podatkov JCR je dovoljen samo uporabnikom iz Slovenije. Vaš trenutni IP-naslov ni na seznamu dovoljenih za dostop, zato je potrebna avtentikacija z ustreznim računom AAI.
Leto | Faktor vpliva | Izdaja | Kategorija | Razvrstitev | ||||
---|---|---|---|---|---|---|---|---|
JCR | SNIP | JCR | SNIP | JCR | SNIP | JCR | SNIP |
Baze podatkov, v katerih je revija indeksirana
Ime baze podatkov | Področje | Leto |
---|
Povezave do osebnih bibliografij avtorjev | Povezave do podatkov o raziskovalcih v sistemu SICRIS |
---|---|
Krčevski-Škvarč, Nevenka | 14310 |
Kamenik, Mirt | 14793 |
Izberite prevzemno mesto:
Prevzem gradiva po pošti
Obvestilo
Gesla v Splošnem geslovniku COBISS
Izbira mesta prevzema
Mesto prevzema | Status gradiva | Rezervacija |
---|
Prosimo, počakajte trenutek.
Naročanje gradiva za izposojo v čitalnice
Naročanje kopij člankov
Urnik dostave gradiva z oznako DS v signaturi