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  • Sprememba p.R577X gena ACTN3 (rs1815739) je povezana s pojavnostjo poškodb slovenskih nogometašic = Variant p.R577X (rs1815739) in ACTN3 gene is associated with frequency of injuries in Slovenian female football players
    Sotlar, Inge ...
    Alpha-actinin-3 is a protein expressed in fast-twitch (type II) muscle fibres. ACTN3 gene variant NM_001104.4:c.1729C>T (p.R577X, rs1815739) in a homozygous state reduces strength, muscle mass, and ... fast-twitch fibre diameter and was asso-ciated with a higher risk of sports injuries and longer exer-cise recovery. We aimed to evaluate the association of the p.R577X with injuries and player position in Slovenian fema-le football players. The study group included 43 participants, with a median age of 16 (13-28) years, who had been acti-vely training football for at least 4 years. ACTN3 p.R577X genotyping was performed with PCR and DdeI restricti-on analysis on saliva DNA. p.R577X in the homozygous or heterozygous state was present in 58.1 % of the players, while 41.9 % had normal genotype. 53.7 % had a four ye-ars history of at least one sports injury. In our study, no sta-tistically significant association was found between ACTN3 p.R577X genotypes and the presence of injuries (p = 0.309), nor between the presence of injuries and player position (p = 0.830) or age dependant category team (p = 0.427). However, we confirmed the association between the presence of inju-ries and the frequencies of each allele (p = 0.037), with the X allele being associated with a higher incidence of injuries.
    Vir: Laboratorijska medicina : znanstveno-strokovno glasilo Slovenskega združenja za klinično kemijo in laboratorijsko medicino. - ISSN 2670-4463 (Št. 3, sep. 2021, str. 76-84)
    Vrsta gradiva - članek, sestavni del ; neleposlovje za odrasle
    Leto - 2021
    Jezik - slovenski
    COBISS.SI-ID - 75086083

    Povezava(-e):

    https://www.szkklm.si/assets/images/upload/LM-03_2021_08_WEB.pdf

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