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  • Influence of dexamethasone on progression of experimental periodontitis in rats = Vpliv deksametazona na razvoj poskusno povzročenega vnetja obzobnih tkiv podgane
    Gašperšič, Rok, 1972- ; Štiblar-Martinčič, Draga ; Skalerič, Uroš, 1945-2023
    Background. Although several clinical observations have reported reduced inflammatory response to bacterial plaque in patients on the prolonged steroidtherapy, the influence of these drugs on ... progression of the periodontaltissue breakdown is still unclear. The aim of this study was to further evaluate the influence of synthetic glucocorticoid decamethasone on progression of the periodontal breakdown in rats. Methods. In rats the periodontitis was induced by placing the silk ligatures around the cervix of the right second maxillary molar. Ten female rats, aged 8 weeks, were divided in two groups: five rats were daily injected with dexamethasone for a period of 14 days; the other injected with dexamethasone for a period of 14 days; theother five rats were injected with saline. Five micro m thick sections of tissue blocks, stained with hematoxylin and eosin were used for the morphometrical analysis, performed on mesial and distal interdental regions ofthe experimental and control teeth. The measurement parameters included the surface of inflammatory infiltrate (SIN), the epithelial attachments loss (EAL), and the distance between the cemento enamel junction and the alveolar bone crest (DAB). Results. The results showed a significantly reduced surface of inflammatory infiltrate (Student's t-test, p <0.01), significantly increased epithelial attachment loss (Student's t-test, p <0.05), and a non significcantly reduced distance between the cemento anemal junction and the alveolar bone crest around the experimental group animals teeth (SIN = 0.006+-0.002 mm2, EAL = 0.17+-0.05 mm, DAB = 0.45+-0.01 mm) as compared to thevalues of the control group (SIN = 0.038+-0.08 mm2, EAL = 0.12+-0.05 mm, DAB = 0.53+-0.01mm).(Abstract truncated at 2000 characters.)
    Vir: Zdravniški vestnik : glasilo Slovenskega zdravniškega društva = Slovenian medical journal = journal of Slovenian Medical Association. - ISSN 1318-0347 (Letn. 67, supl. 2, jun. 1998, str. II-39-II-43)
    Vrsta gradiva - članek, sestavni del
    Leto - 1998
    Jezik - angleški
    COBISS.SI-ID - 7608793

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