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  • Zdravljenje čiste aplastične anemije pri bolniku s kronično limfocitno levkemijo = Treatment of pure red cell aplastic anemia in patient with chronic lymphocytic leukemia
    Bervar, Mojca ; Černelč, Peter
    Background. Pure red cell aplastic anaemia is a very rare complication of chronic lymphocytic leukaemia (CLL). It is probably caused by humoral and/or Tlymphocytec interferance with the growth and ... differentiation of red cell precursors. Most patients with CLL-associated pure red cell aplastic anaemia are treated with immunosuppressive drugs, such as glucocorticoids, cyclosporine or antilymphocyte globulin, and less freqwuently with androgen steroids. Case report. A 68-year-old patient with CLL developed pure red cell aplastic anaemia after 3 years of treatment with chlorambucil and methylprednisolone. Because of advanced CLL, fludarabine was instituted. Two months later, the lymph nodes became smaller and the lymphocyte count decreased, but the anaemia and reticulopoenia persisted. The patient was givencyclosporine (Sandimmun-Neoral) in a dose of 200 mg/day. After a month ofthis treatment, the reticulocyte count increased and the haemoglobin rise to100 g/L. As no further improvement was noted over the next month, cyclosporine was substituted with oxymetholone (Anapolon) 100 mg/day. After a month, the reticulocyte count increased, the haemoglobin reached 126 g/L, and oxymetholone was withdrawn. Conclusion. Since pure red cell aplastic anaemia mostly occus in association with advanced CLL, simultanoeus treeatment of bothdisorders is advisable. Our patient experienced a prolonged remission of the anaemia after treatment with a combination of cyclosporine, androgen steriods and fludarabine.
    Vir: Zdravniški vestnik : glasilo Slovenskega zdravniškega društva = Slovenian medical journal = journal of Slovenian Medical Association. - ISSN 1318-0347 (Letn. 67, supl. 1, maj 1998, str. I-47-I-49)
    Vrsta gradiva - članek, sestavni del
    Leto - 1998
    Jezik - slovenski
    COBISS.SI-ID - 7943129

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