Presenteeism has been an emerging research era, where many exploratory questions may be produced. Literature is not very definitive for the conceptualization of the construct in many aspects. There ...are few studies about the reasons, measurement approaches and positive outcomes of the concept. Studies conducted in Turkish context are even fewer. Paper combines two studies; first study aims to investigate different conceptualizations, possible reasons, negative and positive outcomes of presenteeism. The purpose of the second study is to find out how those concepts structure and relate to each other. Findings provide useful insights for reasons, outcomes and criteria of presenteeism. They also indicate different conceptualization of the concept and there are significant relationships between variables according to the research.
There is growing interest in uncovering genetic kinship patterns in past societies using low‐coverage palaeogenomes. Here, we benchmark four tools for kinship estimation with such data: lcMLkin, ...NgsRelate, KIN, and READ, which differ in their input, IBD estimation methods, and statistical approaches. We used pedigree and ancient genome sequence simulations to evaluate these tools when only a limited number (1 to 50 K, with minor allele frequency ≥0.01) of shared SNPs are available. The performance of all four tools was comparable using ≥20 K SNPs. We found that first‐degree related pairs can be accurately classified even with 1 K SNPs, with 85% F1 scores using READ and 96% using NgsRelate or lcMLkin. Distinguishing third‐degree relatives from unrelated pairs or second‐degree relatives was also possible with high accuracy (F1 > 90%) with 5 K SNPs using NgsRelate and lcMLkin, while READ and KIN showed lower success (69 and 79% respectively). Meanwhile, noise in population allele frequencies and inbreeding (first‐cousin mating) led to deviations in kinship coefficients, with different sensitivities across tools. We conclude that using multiple tools in parallel might be an effective approach to achieve robust estimates on ultra‐low‐coverage genomes.
•Single frequency impedance technique was firstly used for characterization of interaction between HER-3 and anti-HER-3.•Anti-HER-3 antibody was firstly utilized in an immunosensor as a ...bioreceptor.•The biosensor exhibits high analytical performance with a linear range 0.2–1.4pgmL−1.•Kramers–Kronig transform was successfully performed on the experimental impedance data.
We have developed a new immunological biosensor for ultrasensitive quantification of human epidermal growth factor receptor-3(HER-3). In order to construct the biosensor, the gold electrode surface was layered with, hexanedithiol, gold nanoparticles, and cysteamine, respectively. Anti-HER-3 antibody was covalently attached to cysteamine by glutaraldehyde and used as a bioreceptor in a biosensor system for the first time by this study. Surface characterization was obtained by means of electrochemical impedance spectroscopy and voltammetry. The proposed biosensor showed a good analytical performance for the detection of HER-3 ranging from 0.2 to 1.4pgmL−1. Kramers–Kronig transform was performed on the experimental impedance data. Moreover, in an immunosensor system, the single frequency impedance technique was firstly used for characterization of interaction between HER-3 and anti-HER-3. Finally the presented biosensor was applied to artificial serum samples spiked with HER-3.
Abstract Malignancy risk calculation models were developed using the clinical and radiological features. It was aimed to compare pulmonary nodule risk calculation models and evaluate their ...effectiveness and applicability for the Turkish population. Between 2014 and 2019, 351 patients who were operated on for pulmonary nodules were evaluated with the following data: age, gender, smoking history, family history of lung cancer, extrapulmonary malignancy and granulomatous disease, nodule diameter, attenuation character, side, localization, spiculation, nodule count, presence of pulmonary emphysema, FDG uptake in PET/CT of the nodule, and definitive pathology data. Malignancy risk scores were calculated using the equations of the Brock, Mayo, and Herder models. The results were evaluated statistically. The mean age of the 351 patients (236 men, 115 women) was 57.84 ± 10.87 (range 14–79) years, and 226 malignant and 125 benign nodules were observed. Significant correlations were found between malignancy and age ( p < 0.001), nodule diameter ( p < 0.001), gender ( p < 0.009), speculation ( p < 0.001), emphysema ( p < 0.05), FDG uptake ( p < 0.001). All three models were found effective in the differentiation ( p < 0.001). The ideal threshold value was determined for the Brock (19.5%), Mayo (23.1%), and Herder (56%) models. All models were effective for nodules of > 10 mm, but none of them were for 0–10 mm. Brock was effective in ground - glass nodules ( p = 0.02) and all models were effective for semi-solid and solid nodules. None of the groups could provide AUC values as high as those achieved in the original studies. This suggests the need to optimize models and malignancy risk thresholds for Turkish population.
In this work, nine drug precursors, 2-(4,5-dimethyl-1-(phenylamino)-1H-imidazol-2-ylthio)-N-(benzothiazole-2-yl) acetamide derivative compounds, were newly synthesized by reacting ...4,5-dimethyl-1-(phenylamino)-1H-imidazole-2(3H)-thione derivatives with 2-chloro-N-(thiazol-2-yl) acetamide compounds. Structures of the synthesized compounds were confirmed by 1H NMR, FTIR (Fourier transform infrared), MS (mass spectroscopy), and elemental analysis. The acidity constants of these acetamide derivatives were determined via UV spectroscopic studies. It was found that the first protonation of these compounds occurs on the nitrogen at imidazole ring, while the second protonation of these compounds occurs on the nitrogen at benzothiazole ring. The first pK a values were found to vary between 5.91 and 8.34 while the second pK a values were varying between 3.02 and 4.72.
We compared the mechanical properties of two fixation techniques for the treatment of extra-articular distal third humeral fractures.
Two groups were created from twenty-four humeri. Group 1 was ...instrumented using a new, precontoured, 8-hole (3.5-mm-diameter) locking compression plate (LCP) placed anterolaterally. Group 2 was instrumented using an 8-hole (3.5-mm-diameter) precontoured posterolateral LCP plate placed on the distal humerus. Four-point bending tests and torsion tests were performed until the specimens broke.
The four-point bending stiffness test showed that the stiffness of anterolaterally fixed humeri was significantly higher than that of posterolaterally fixed humeri (p<0.05). Torsion testing revealed that posterolateral fixation was associated with better yield strength (p<0.05), but the torsional stiffness did not differ significantly between the two plates (p> 0.05).
The anterolateral plate exhibited higher bending stiffness and torsional yield strength than the posterolateral plate. Anterolateral plate fixation can thus be used to manage extra-articular distal humeral fractures. Multiaxial locking screws ensure rigid fixation, allow early elbow motion without olecranon fossa impingement, and prevent iatrogenic injury of the triceps muscle.
Background
Laparoscopic sleeve gastrectomy (LSG) has become a popular procedure for treating obesity. Excessive residual gastric volume (RGV) may be one cause of insufficient weight loss following ...this surgery. The purpose of this study was to investigate the relationship between weight loss and the RGV measured during surgery over a 2-year follow-up period.
Methods
All patients undergoing LSG at our university surgery department were included in this prospective observational study. During the operation, the pylorus was grasped with a laparoscopic clamp, and saline solution dyed with methylene blue was introduced using an intraluminal glass-tipped injector when the residual stomach became fully visible. The amount of fluid given when the remaining gastric tissue ceased expanding was noted. The patients were divided into three groups depending on the volume of the residual gastric tissue. Percentages of excess weight loss (EWL%) were also evaluated 6, 12, and 24 months after the LSG.
Results
Sixty-two patients (50 females and 12 males) with a mean age of 36 (17–56) years were included in the study. There was no significant difference between the preoperative and postoperative body mass index values (
p
= 0.407 and
p
= 0.337, respectively) or between the preoperative and postoperative weight (
p
= 0.081 and
p
= 0.517, respectively) among the groups. A comparison of the participants’ weight losses and EWL% values after 6, 12, and 24 months of follow-up revealed no significant difference among the groups at any time point (
p
> 0.005).
Conclusion
Greater weight loss was observed as the RGV decreased over the 24-month follow-up period. However, that weight loss was not statistically significant.
In the quarter of a century before the First World War, there were numerous economic and political developments that shaped the Allied and Entente blocs. The Moroccan crisis holds a decisive place ...within these developments. The struggle of the Western Powers to share Morocco at the beginning of the 20th century was at the center of the crisis. The unequal bilateral relations developed between the Ottoman Empire and the Western Powers during the process of opening up to capitalism influenced the foreign policy as well as the economic policies of the state. In this study, the economic, political and social foundations of the policies followed by the Ottoman Empire during the crisis in Morocco, which was both its neighbor in terms of its domination area and its ideological rival in the Islamic world, are discussed using primary sources. In this context, the aim of the study is to reveal whether the Ottoman Empire, depending on its perception of threat, tried to implement a set of reactive, preventive, and supportive policies towards Morocco in terms of military, political, or economic aspects. The findings of the study show that the policies implemented are carried out on a political and military basis and through indirect channels. As a matter of fact, the Ottoman Empire's approach to the Moroccan crises was shaped by Pan-Islamist policies under the influence of Germany, the preservation of its sovereign rights in North Africa, the protection of its subjects in the region, and the question of nationality and the repercussions of the Franco-German rivalry in Morocco on the Ottoman country.
The aim of this study was to evaluate the behaviour and knowledge skill levels of Turkish orthopedic surgeons about fluoroscopy usage and radiation safety.
The questionnaire, consisting of nineteen ...questions, was sent to orthopaedic surgeons and requested by a total of 323 surgeons online. The questions were about personal information, training and behaviours related to radiation and fluoroscopy usage, and the use of protective equipment.
A total of 277 individuals completed the questionnaire. The answers of 180 surgeons whose working duration was more than 1 year and also who participated in at least one fluoroscopy requiring operation per week, were analysed. 22 (12%) participants answered that they were trained on fluoroscopy usage. Sixty people (33.3%) reported that they did not use any protective equipment regularly. The most commonly used protection methods were lead aprons 123 (68.3%). Thyroid protectors were used by 92 participants (52.1%). There was no significant difference between the groups when comparing the use of protective equipment according to the academic title. Only 19 (10.6%) of the surgeons noted that they used dosimeter regularly, and 15 (83.3%) of them reported that they controlled their dosimeters.
In this study, Orthopedic surgeons were found not to be adequately trained about use and risks of fluoroscopy and also not to be equipped about methods for preventing radiation damage.
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