Introduction
Existing evidence in the association between maternal pregnancy and pre-pregnancy weight and behavioural outcomes in children.
Objectives
This study aimed to examine these associations ...at six developmental time-points between ages 3 and 16.
Methods
We used data from the Avon Longitudinal Study of Parents and Children (ALSPAC), an ongoing population-based longitudinal pregnancy cohort study in Bristol, United Kingdom (UK). Data on behavioural outcomes were measured at ages 3.5, 7, 9, 11 and 16 years using the Strengths and Difficulties Questionnaire (SDQ). Over 7960 (at 3.5 years of age) and 4400 (at 16 years of age) mother-child pairs were included in the final analysis. Logistic regression analyses were used to examine the associations.
Results
Pre-pregnancy BMI and gestational weight gain were associated with total behavioural difficulties in children across all age groups. In separate analyses using each SDQ subscale, however, we found that pre-pregnancy underweight was associated with emotional problems at ages 7 (OR = 1.66, 95% CI; 1.20 – 2.29), 11 (OR = 1.49, 95% CI; 1.02 – 2.18) and 16 (OR = 1.74, 95% CI; 1.16 – 2.60) years and hyperactivity/inattention problems at age 16 (OR = 1.96, 95% CI; 1.27 – 3.05). We also found an association between guideline-discordant gestational weight gain and peer relationship problems at age 9 and pro-social behaviour at ages 9 and 11.
Conclusions
Our findings highlight that pre-pregnancy underweight than overweight, obesity or gestational weight gain may influence the emotional health of children and adolescents.
Disclosure of Interest
None Declared
Background
Multidrug‐resistant tuberculosis (MDR‐TB) is a major global public health concern. However, there is a dearth of literature on whether MDR‐TB and its medications impact maternal and ...perinatal outcomes, and when such evidence exists the findings are conflicting.
Objectives
This systematic review and meta‐analysis aimed to examine the impact of MDR‐TB and its medications during pregnancy on maternal and perinatal outcomes.
Search strategy
PubMed, Scopus and Web of Science databases were searched from earliest to February 2020.
Selection criteria
Records were screened based on pre‐defined selection criteria and assessed for quality by two independent reviewers.
Data collection and analysis
A meta‐analysis was performed using the random effects model to calculate pooled prevalence for each outcome.
Main results
Of the 72 records identified, 12 were included in the systematic review and meta‐analysis, consisting of 174 pregnant women with MDR‐TB and 110 adverse outcomes. Maternal death, pregnancy loss, preterm birth and low birthweight were the most common maternal and perinatal adverse outcomes reported in the studies. The overall pooled prevalence was 7.5% (95% CI 3.2–12.8) for maternal death, 10.6% (95% CI 6.0–16.3) for pregnancy loss, 12.9% (95% CI 0.0–38.0) for preterm birth and 23.7% (95% CI 17.0–31.0) for low birthweight.
Conclusions
The findings suggest that MDR‐TB is associated with a high risk of adverse maternal and perinatal outcomes, but these should be interpreted cautiously because the evidence is largely preliminary. Adequately powered prospective cohort studies are urgently required to corroborate these findings.
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Multidrug‐resistant tuberculosis may increase the risk of adverse maternal and perinatal outcomes.
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Multidrug‐resistant tuberculosis may increase the risk of adverse maternal and perinatal outcomes.
Maternal obesity, usually associated with the adverse birth outcomes, has been a serious public health concern. Studies examining its effect on the physical and cognitive development of children have ...only recently emerged and the findings are inconsistent. This review aimed to systematically examine the role of maternal obesity on children's physical and cognitive development using the available evidence.
The CINAHL, EMBASE, PSYCINFO, PUBMED and SCOPUS databases were searched. Studies addressing children's (⩽12 years) physical and cognitive development as outcome and maternal pre-pregnancy body mass index as an exposure were included. Data were extracted and evaluated for quality by two independent reviewers.
A total of 17 articles were eligible for this systematic review; 10 of them were birth cohorts from the USA. Nine of the 14 studies supported an adverse association between maternal pre-pregnancy obesity and childhood cognitive development. A few studies also demonstrated a negative association between the maternal obesity and gross motor function in children (5 of 10), but not with fine motor function (none out of five studies). Whether the observed negative association between the maternal obesity and children's cognitive and gross motor abilities is casual or due to residual confounding effects is unclear. The current evidence is based on a limited number of studies with heterogeneous measurement scales and obesity definition.
From the available evidence, it seems that exposure to maternal pre-pregnancy obesity in the intrauterine environment has a detrimental effect on children's cognitive development. However, evidence of the association between the maternal obesity and physical development of children is too scarce to offer a conclusion. More research work is required to delineate the intrauterine effect of the maternal obesity from the residual confounding effects.
Context. Millimetre-wave continuum astronomy is today an indispensable tool for both general astrophysics studies (e.g. star formation, nearby galaxies) and cosmology (e.g. cosmic microwave ...background and high-redshift galaxies). General purpose, large-field-of-view instruments are needed to map the sky at intermediate angular scales not accessible by the high-resolution interferometers (e.g. ALMA in Chile, NOEMA in the French Alps) and by the coarse angular resolution space-borne or ground-based surveys (e.g. Planck, ACT, SPT). These instruments have to be installed at the focal plane of the largest single-dish telescopes, which are placed at high altitude on selected dry observing sites. In this context, we have constructed and deployed a three-thousand-pixel dual-band (150 GHz and 260 GHz, respectively 2 mm and 1.15 mm wavelengths) camera to image an instantaneous circular field-of-view of 6.5 arcmin in diameter, and configurable to map the linear polarisation at 260 GHz. Aims. First, we are providing a detailed description of this instrument, named NIKA2 (New IRAM KID Arrays 2), in particular focussing on the cryogenics, optics, focal plane arrays based on Kinetic Inductance Detectors, and the readout electronics. The focal planes and part of the optics are cooled down to the nominal 150 mK operating temperature by means of an adhoc dilution refrigerator. Secondly, we are presenting the performance measured on the sky during the commissioning runs that took place between October 2015 and April 2017 at the 30-m IRAM telescope at Pico Veleta, near Granada (Spain). Methods. We have targeted a number of astronomical sources. Starting from beam-maps on primary and secondary calibrators we have then gone to extended sources and faint objects. Both internal (electronic) and on-the-sky calibrations are applied. The general methods are described in the present paper. Results. NIKA2 has been successfully deployed and commissioned, performing in-line with expectations. In particular, NIKA2 exhibits full width at half maximum angular resolutions of around 11 and 17.5 arcsec at respectively 260 and 150 GHz. The noise equivalent flux densities are, at these two respective frequencies, 33±2 and 8±1 mJy s1/2. A first successful science verification run was achieved in April 2017. The instrument is currently offered to the astronomy community and will remain available for at least the following ten years.
The prototype of the NIKA2 camera, NIKA, is a dual-band instrument operating at the IRAM 30-m telescope, which can observe the sky simultaneously at 150 and 260 GHz. One of the main goals of NIKA ...(and NIKA2) is to measure the pressure distribution in galaxy clusters at high angular resolution using the thermal Sunyaev-Zel’dovich (tSZ) effect. Such observations have already proved to be an excellent probe of cluster pressure distributions even at intermediate and high redshifts. However, an important fraction of clusters host sub-millimeter and/or radio point sources, which can significantly affect the reconstructed signal. Here we report on <20 arcsec angular resolution observations at 150 and 260 GHz of the cluster MACS J1423.8+2404, which hosts both radio and sub-millimeter point sources. We examine the morphological distribution of the tSZ signal and compare it to other datasets. The NIKA data are combined with Herschel satellite data to study the spectral energy distribution (SED) of the sub-millimeter point source contaminants. We then perform a joint reconstruction of the intracluster medium (ICM) electronic pressure and density by combining NIKA, Planck, XMM-Newton, and Chandra data, focusing on the impact of the radio and sub-millimeter sources on the reconstructed pressureprofile. We find that large-scale pressure distribution is unaffected by the point sources because of the resolved nature of the NIKA observations. The reconstructed pressure in the inner region is slightly higher when the contribution of point sources are removed. We show that it is not possible to set strong constraints on the central pressure distribution without accurately removing these contaminants. The comparison with X-ray only data shows good agreement for the pressure, temperature, and entropy profiles, which all indicate that MACS J1423.8+2404 is a dynamically relaxed cool core system. The present observations illustrate the possibility of measuring these quantities with a relatively small integration time, even at high redshift and without X-ray spectroscopy. This work is part of a pilot study aiming at optimizing tSZ observations with the future NIKA2 camera.
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•Binary acids corncob pretreatment achieved 93.5 ± 1.3% cellulose recovery.•Binary acids pretreatment removed ≈85% of hemicellulose and lignin.•Pretreated corncob biomass was ...characterized using FTIR, XRD and SEM.•Hydrolysates of corncob biomass yielded 24.6 mg/mL bioethanol.
Lignocellulosic agricultural wastes are the most widely utilized resource for bioethanol production due to several advantages. Removal of hemicellulose and lignin is a prerequired step during bioethanol production from lignocellulosic biomass to upgrade cellulose recovery and the substrate porosity for saccharification. Chemical pretreatment of corncob was performed in the current research applying binary acids (H2SO4 + CH3COOH) in different ratios. The attained maximum removal of lignin and hemicellulose were 81.41 ± 2.3% and 85.6 ± 1.8%, respectively, with enhanced cellulose recovery of 93.5 ± 1.3% at the optimum conditions of binary acids concentration (3%, v/v), biomass loading ratio (0.1 g/mL), pretreatment temperature (120 °C) and time (60 min). The SEM, FTIR and XRD results revealed the removal of hemicelluloses and lignin from the corncob biomass by binary acids pretreatment and confirmed a change in the crystallinity index of corncob biomass. Ethanol fermentation was accomplished at 30 °C at 200 rpm for 4 days with the hydrolysates using Saccharomyces cerevisiae and obtained a maximum bioethanol concentration of 24.6 mg/mL. This study demonstrates that binary acids pretreatment is an alternative approach for the pretreatment of lignocellulosic biomass. The optimized process conditions could also increase cellulose recovery and bioethanol yield.
Reported associations of pre-pregnancy weight and/or gestational weight gain with offspring behavioural outcomes are inconsistent. Using data from the Avon Longitudinal Study of Parents and Children ...(ALSPAC), this study aimed to examine these associations at five developmental stages between the ages of 3 and 16. Over 6800 mother-offspring pairs at age 3 and 3925 pairs at age 16 were included. Pre-pregnancy underweight was associated with a 22% increased risk of total behavioural difficulties (OR = 1.22, 95% CI 1.02-1.45). In separate analyses using the SDQ subscales, pre-pregnancy underweight was linked to a 37% (OR = 1.37, 95% CI 1.14-1.65) and 33% (OR = 1.33, 95% CI 1.01-1.76) increased risk of emotional symptoms and prosocial behaviour problems over time, respectively. While pre-pregnancy overweight was associated with an 11% (OR = 1.11, 95% CI 1.03-1.20) and 18% (OR = 1.18, 95% CI 1.03-1.36) increased risk of conduct and peer relationship problems, respectively, pregnancy obesity was associated with a 43% increased risk of emotional problems (OR = 1.43, 95% CI 1.16-1.77). We found no evidence of associations between gestational weight gain and child behaviour except for a reduced risk in prosocial behaviour problems (OR = 0.82, 95% CI 0.70-0.96). Our findings provide insights into the link between preconception BMI and child behaviour, underscoring the necessity for further research to validate these associations and elucidate underlying mechanisms.
New IRAM KID array 2 (NIKA2) is a camera dedicated to millimeter-wave astronomy based upon kilopixel arrays of kinetic inductance detectors
1
(KID). The pathfinder instrument, NIKA
2
, has already ...shown state-of-the-art detector performance. NIKA2 builds upon this experience but goes one step further, increasing the total pixel count by a factor
∼
10 while maintaining the same per pixel performance. For the next decade, this camera will be the resident photometric instrument of the Institut de Radio Astronomie Millimetrique (IRAM) 30 m telescopes in Sierra Nevada (Spain). In this paper, we give an overview of the main components of NIKA2 and describe the achieved detector performance. The camera has been permanently installed at the IRAM 30 m telescope in October 2015. It will be made accessible to the scientific community at the end of 2016, after a 1-year commissioning period. When this happens, NIKA2 will become a fundamental tool for astronomers worldwide.
The New IRAM KID Array (NIKA) instrument is a dual-band imaging camera operating with kinetic inductance detectors (KID) cooled at 100 mK. NIKA is designed to observe the sky at wavelengths of 1.25 ...and 2.14 mm from the IRAM 30 m telescope at Pico Veleta with an estimated resolution of 13 arcsec and 18 arcsec, respectively. This work presents the performance of the NIKA camera prior to its opening to the astrophysical community as an IRAM common-user facility in early 2014. NIKA is a test bench for the final NIKA2 instrument to be installed at the end of 2015. The last NIKA observation campaigns on November 2012 and June 2013 have been used to evaluate this performance and to improve the control of systematic effects. We discuss here the dynamical tuning of the readout electronics to optimize the KID working point with respect to background changes and the new technique of atmospheric absorption correction. These modifications significantly improve the overall linearity, sensitivity, and absolute calibration performance of NIKA. This is proved on observations of point-like sources for which we obtain a best sensitivity (averaged over all valid detectors) of 40 and 14 mJy s1/2 for optimal weather conditions for the 1.25 and 2.14 mm arrays, respectively. NIKA observations of well known extended sources (DR21 complex and the Horsehead nebula) are presented. This performance makes the NIKA camera a competitive astrophysical instrument.
The thermal Sunyaev-Zel’dovich (tSZ) effect is expected to provide a low scatter mass proxy for galaxy clusters since it is directly proportional to the cluster thermal energy. The tSZ observations ...have proven to be a powerful tool for detecting and studying them, but high angular resolution observations are now needed to push their investigation to a higher redshift. In this paper, we report high angular (<20 arcsec) resolution tSZ observations of the high-redshift cluster CL J1226.9+3332 (z = 0.89). It was imaged at 150 and 260 GHz using the NIKA camera at the IRAM 30-m telescope. The 150 GHz map shows that CL J1226.9+3332 is morphologically relaxed on large scales with evidence of a disturbed core, while the 260 GHz channel is used mostly to identify point source contamination. NIKA data are combined with those of Planck and X-ray from Chandra to infer the cluster’s radial pressure, density, temperature, and entropy distributions. The total mass profile of the cluster is derived, and we find M500 = 5.96+1.02-0.79 × 1014M⊙ within the radius R500 = 930+50-43 kpc, at a 68% confidence level. (R500 is the radius within which the average density is 500 times the critical density at the cluster’s redshift.) NIKA is the prototype camera of NIKA2, a KIDs (kinetic inductance detectors) based instrument to be installed at the end of 2015. This work is, therefore, part of a pilot study aiming at optimizing tSZ NIKA2 large programs.
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