Nutrients are essential for the healthy development and proper maintenance of body functions in humans. For adequate nourishment, it is important to keep track of nutrients level in the body, apart ...from consuming sufficient nutrition that is in line with dietary guidelines. Sweat, which contains rich chemical information, is an attractive biofluid for routine non‐invasive assessment of nutrient levels. Herein, a wearable sensor that can selectively measure vitamin C concentration in biofluids, including sweat, urine, and blood is developed. Detection through an electrochemical sensor modified with Au nanostructures, LiClO4‐doped conductive polymer, and an enzymes‐immobilized membrane is utilized to achieve wide detection linearity, high selectivity, and long‐term stability. The sensor allows monitoring of temporal changes in vitamin C levels. The effect of vitamin C intake on the sweat and urine profile is explored by monitoring concentration changes upon consuming different amounts of vitamin C. A longitudinal study of sweat's and urine's vitamin C correlation with blood is performed on two individuals. The results suggest that sweat and urine analysis can be a promising method to routinely monitor nutrition through the sweat sensor and that this sensor can facilitate applications such as nutritional screening and dietary intervention.
A wearable nutrient tracker that allows monitoring of vitamin C in sweat, along with urine and blood, to assist tracking users’ nutritional status is demonstrated. A longitudinal study is performed on two individuals to explore correlations of vitamin C concentrations in sweat and urine with blood. It has promising potential applications in nutritional assessment and dietary intervention.
Rosacea Pathogenesis Ahn, Christine S; Huang, William W
Dermatologic clinics
36, Številka:
2
Journal Article
Recenzirano
Rosacea is a chronic inflammatory skin disorder that is not fully understood but involves the complex interplay of genetic factors, immune dysregulation, neurovascular dysregulation, presence of ...microorganisms, and environmental factors. Increased activation of the immune system occurs through multiple stimuli, including increased levels of cathelicidin and kallikrein 5, Toll-like receptor 2, matrix metalloproteinases, and mast cells within the skin. Their effects are enhanced by the presence of microorganisms and external triggers, such as UV radiation.
Malignant Sweat Gland Tumors Ahn, Christine S; Sangüeza, Omar P
Hematology/oncology clinics of North America,
02/2019, Letnik:
33, Številka:
1
Journal Article
Recenzirano
Malignant sweat gland neoplasms are a confusing area within dermatopathology, with many entities reported under several designations in the literature. This review describes the key clinical and ...histopathologic features of select malignant adnexal neoplasms, including porocarcinoma, papillary carcinoma, adenoid cystic carcinoma, cribriform carcinoma, apocrine hidradenocarcinoma, malignant mixed tumor of the skin, syringoid carcinoma, cylindrocarcinoma, spiradenocarcinoma, mucinous carcinoma, polymorphous sweat gland carcinoma, microcystic adnexal carcinoma, secretory carcinoma of the skin, and primary cutaneous signet ring cell carcinoma. For entities with overlapping features, differential diagnoses are discussed.
BACKGROUND:Previous studies have demonstrated a lack of diversity in orthopaedics; however, it is unclear whether this observation is unique to orthopaedics or similar to other surgical fields. The ...present study compares diversity in the field of orthopaedics with diversity in other surgical and nonsurgical fields. To our knowledge, no previous study has placed this issue in a comparative perspective between specialties at both the residency and faculty levels.
METHODS:Public registries from 2006 and 2007 were used to determine the composition (according to race, ethnicity, and sex) of the orthopaedic workforce in the United States, including medical students, orthopaedic residents, orthopaedic faculty, and full professors. The diversity of orthopaedic residents and faculty was then compared with that in five other specialties. In addition, the applicant pools to orthopaedic and general surgery residencies were compared.
RESULTS:Within the 2006 orthopaedic workforce, there was a significant decrease in the representation of African-Americans, Hispanics/Latinos, Asian-Americans, and women from medical schools to orthopaedic residencies (p < 0.001). African-Americans, Hispanics/Latinos, and Asian-Americans were underrepresented among orthopaedic faculty compared with their representation in orthopaedic residency programs (p < 0.05). Furthermore, women and Asian-Americans were disproportionately underrepresented as full professors compared with their presence on the faculty at academic orthopaedic institutions (p < 0.05). When compared with other surgical specialties, African-Americans and Hispanics/Latinos made up a significantly smaller proportion of orthopaedic residents than general surgery residents and neurological surgery. Orthopaedic surgery had the lowest representation of female residents and faculty (p < 0.05 for all comparisons). In examining the applicant pool, orthopaedic surgery was less diverse than general surgery (p < 0.001). Furthermore, African-American and Hispanic/Latino orthopaedic applicants also submitted a lower average number of applications than Whites or Asian-Americans.
CONCLUSIONS:Our findings suggest that on a comparative basis, orthopaedic surgery lags behind general surgery and other surgical and nonsurgical fields in terms of the representation of minorities and women. Thus, given similar capabilities and qualifications of applicants, a concerted effort could be made to recruit more diverse residents and faculty.
The body naturally and continuously secretes sweat for thermoregulation during sedentary and routine activities at rates that can reflect underlying health conditions, including nerve damage, ...autonomic and metabolic disorders, and chronic stress. However, low secretion rates and evaporation pose challenges for collecting resting thermoregulatory sweat for non-invasive analysis of body physiology. Here we present wearable patches for continuous sweat monitoring at rest, using microfluidics to combat evaporation and enable selective monitoring of secretion rate. We integrate hydrophilic fillers for rapid sweat uptake into the sensing channel, reducing required sweat accumulation time towards real-time measurement. Along with sweat rate sensors, we integrate electrochemical sensors for pH, Cl
, and levodopa monitoring. We demonstrate patch functionality for dynamic sweat analysis related to routine activities, stress events, hypoglycemia-induced sweating, and Parkinson's disease. By enabling sweat analysis compatible with sedentary, routine, and daily activities, these patches enable continuous, autonomous monitoring of body physiology at rest.
An aqueous emulsion of conducting polymer is commonly applied on a substrate to form a coating after drying. The coating, however, disintegrates in water. This paper reports a coating prepared using ...a mixture of two emulsions: an aqueous emulsion of conducting polymer, and an aqueous emulsion of hydrophobic and rubbery chains copolymerized with silane coupling agents. When applied on a substrate and dried, particles of the mixed emulsion merge into a continuous film. While the conducting polymer forms percolated nanocrystals, the silane groups crosslink the rubbery chains and interlink the rubbery chains to the substrate. The percolated nanocrystals make the coating highly conductive. The covalent network of hydrophobic polymer chains stabilizes the coating in water. The high conductivity and stability in water may enable broad applications.
A conducting polymer coating is prepared by a mixture of two emulsions: an aqueous emulsion of conducting polymer, and an aqueous emulsion of hydrophobic and rubbery chains copolymerized with silane coupling agents. The coating features percolated nanocrystals which make the coating highly conductive, and the hydrophobic covalent network which stabilizes the coating in water.
The incidence of metastatic melanoma continues to increase each decade. Although surgical treatment is often curative for localized stage I and stage II disease, the median survival for patients with ...distant metastases is less than 1 year. The last 2 decades have witnessed a breakthrough in therapeutic options with the development of immune checkpoint inhibitors, small molecule targeted therapy, and oncolytic viral therapy. This article provides an overview of the treatment options available for advanced melanoma, including chemotherapy, targeted therapy, immunotherapy, interleukin-2, and oncolytic viral agents.
Dermatofibrosarcoma protuberans (DFSP) is an uncommon dermal neoplasm that exhibits a high rate of local recurrence and infiltrative behavior, but has a low risk of metastasis. It arises as a slowly ...progressive, painless pink or violet plaque. Histologically, DFSP is characterized by a monomorphous spindle cell proliferation in a storiform pattern. The gold standard of treatment is surgical resection with negative margins. In cases where obtaining clear margins is not possible, radiation and systemic therapy with tyrosine kinase inhibitors, such as imatinib mesylate, has been shown to be effective.
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