Protic ionic
liquids (PILs) having tris(2-hydroxyethyl)ammonium (or triethanolammonium) as
cations and methacrylate, dihydrogenborate, formate, acetate as anions have
been synthesized through ...stoichiometric neutralization reaction. PILs have been
characterized by elemental analyses, FTIR, 1H and 13C NMR
spectroscopic methods. The viscosity of PIL4
was measured using a cone-and-plate viscometer at ambient temperature. The
viscosity value indicates that the fluidity of PIL4 is 829 cP (the water viscosity is 0.7977 cP at 30 °C).
The enhancement of hole injection layers is strongly important issue for obtaining high-efficient and low-driving-voltage Organic Light-Emitting Devices (OLEDs). In this paper, we presented a ...comprehensive electroluminescence (EL) study of phosphazene-based ionic liquids (PzILs) used as a hole transport layer in solution-processed OLEDs. Charge transfer properties of PzILs were investigated by doping in poly(3,4-ethylenedioxythiophene) polystyrene sulfonate (PEDOT:PSS) at different ratios (0.1, 0.2, 0.5, 1.0, 2.0). Previously synthesized four types of PzILs (namely PzIL1, PzIL2, PzIL3, and PzIL4) were prepared in de-ionized water with 10 mg/ml concentration, mixed with PEDOT:PSS and examined for their charge transport characteristics on OLED device performance due to their ionic nature. The device with PzIL1 exhibited the best performance with luminance 4185 cd/m
2
compared to other devices with and without PzILs. Further, Density Functional Theory (DFT) calculations and admittance spectroscopic analysis of OLEDs based on four types of PzILs were studied profoundly. Admittance spectroscopy has been used for revealing the carrier transport properties, mobility and the equivalent circuit modeling of the devices. Four types of PzILs OLEDs represented typical p-type transporting characteristics with moderate mobility up to 1.93 cm
2
/V.s.
The quaternized compounds (PzIL1-9) reacted with sodium tetrafluoroborate (NaBF
) to generate phosphazene based ionic liquids (PzILs), PzIL1a-9a. The newly synthesized ionic compounds (PzIL1a-9a) ...were verified using elemental CHN analyses and functional and spectroscopic (FTIR and
H,
C,
P-NMR) analyses techniques. The thermal properties of PzIL1a-9a were investigated using thermogravimetric analysis (TGA). According to the initial decomposition temperature values calculated based on the TGA thermograms, PzIL7a (213 °C) was recognized to be more thermally stable than the other PzILs studied. PzIL1a-9a exhibited good solubility in the water and demonstrate a typical dielectric relaxation behavior, conductivity levels for both low and high-frequency regions. AC conductivity mechanisms and dielectric relaxation behavior of each sample are investigated by fabricating parallel plate capacitors.
Display omitted
•New bis(2-furanylmethyl)spiro(N/N)cyclotriphosphazenes and some quaternized derivatives were prepared.•The characteristic NMR spectral data of the phosphazenes were elucidated.•The ...crystal structures of two phosphazenes were determined crystallographically.•The antioxidant activities of the phosphazenes were evaluated.
In the present study, the reaction of hexachlorocyclotriphosphazene (N3P3CI6, HCCP) and N1,N2-bis(2-furanylmethyl)-1,2-diaminoethane (1) yielded the tetrachloro-spiro(ethane-1,2-diamino)-N,N-bis(2-furanylmethyl)cyclotriphosphazene (2). Tetrachlorocyclotriphosphazene (2) was then converted to fully substituted cyclotriphosphazenes (2a-2e) using secondary amines and sodium dimethylaminoethoxide. Compound 2e with dimethylaminoethoxy chains was quaternized in substituted nitrogen by reacting with methyl iodide (CH3I) to give polyiodo salt (2f). Subsequent metathesis with bis(trifluoromethane)sulfonimide lithium salt (LiNTf2) gave the corresponding ionic salt (2g). This phosphazene-based amide salt (2g) arose as a viscous liquid at room temperature. The structures of 2–2g were confirmed by elemental analysis, HRMS, FT-IR, 1H, 13C, and 31P NMR data. The crystal structures of 2 and 2b were also elucidated by X-ray crystallography. Additionally, the antioxidant activities of the phosphazene derivatives were investigated using free radical scavenging assays. The highest radical scavenging activity values (%) were detected for compounds 2e (53.4 ± 0.4) and 2f (56.1 ± 0.2).
The quaternized compounds (PzIL1–9) reacted with sodium tetrafluoroborate (NaBF4) to generate phosphazene based ionic liquids (PzILs), PzIL1a–9a. The newly synthesized ionic compounds (PzIL1a–9a) ...were verified using elemental CHN analyses and functional and spectroscopic (FTIR and 1H, 13C, 31P-NMR) analyses techniques. The thermal properties of PzIL1a–9a were investigated using thermogravimetric analysis (TGA). According to the initial decomposition temperature values calculated based on the TGA thermograms, PzIL7a (213 °C) was recognized to be more thermally stable than the other PzILs studied. PzIL1a–9a exhibited good solubility in the water and demonstrate a typical dielectric relaxation behavior, conductivity levels for both low and high-frequency regions. AC conductivity mechanisms and dielectric relaxation behavior of each sample are investigated by fabricating parallel plate capacitors.
The reaction of o-aminophenol with para hydroxy and methoxy substituted benzaldehydes yielded two Schiff bases. These Schiff bases functioning precursors were turned into palladium complexes by ...treating palladium acetate. The structural formulas based on spectral methods (elemental analysis, FT-IR spectroscopy, NMR spectroscopy and QTOF-LC/MS spectroscopy) were suggested for obtained both complexes. According to the structural characterization methods, one of the complexes had also an acetate co-ligand along with the hydroxy substituted Schiff base ligand. In the other complex, the palladium central ion was proposed to be coordinated with two methoxy substituted Schiff bases. Besides, DPPH scavenging activities of the all synthesized compounds were determined and compared to well-known antioxidant standards. According to the results, antioxidant activities of the palladium complexes was mild but lower than parent Schiff bases.
Four new dicyanoargentate(I)-based complexes 1-4 were synthesized from certain metal ions with a tetradentate ligand N, N-bis (2-hydroxyethyl) -ethylenediamine; N-bishydeten and determined by diverse ...procedures (elemental, thermal, FT-IR, ESI-MS for 1-3 and, magnetic susceptibility and EPR for 1, and 2) including crystal analysis of 4. The crystal method revealed that complex 4 has a sandwich-type like polymeric chemical structure with layers formed by Cd(N-bishydeten)
cations and Ag(CN)
anions. The complexes were further characterized by fluorescence and UV spectroscopy to determine their physicochemical features. The complexes displayed a DNA binding activity within the same range as found for cisplatin, in addition to their strong stability in the presence of the physiological buffer system. The complexes were also investigated for pharmacological properties like interaction with DNA/Bovine serum albumin, anticancer and antibacterial activities. Physicochemical studies of DNA with the complexes suggested that the interaction mode between them are possibly both intercalative and groove binding types. These spectroscopic measurements also show that there may be a binding tendency between BSA and the complexes via hydrogen or Van der Waals bonds. The viability tests demonstrated that all the complexes exhibited antibacterial (1-4) and anticancer effects (2-4) toward ten diverse bacterial strains and three tumor cells (HT-29 colon adenocarcinoma, HeLa cervical cancer, and C6 glioma), respectively.
The study included the synthesis of manganese dioxide nanoparticles using the nitric acid by oxidation method. Moreover, the work involved the chemical synthesis of Ag metal nanoparticles using ...sodium citrate for reducing Ag ion into Ag metal in its nanoscale form. These nanoparticles were diagnosed using FTIR, XRD, and AFM. The maximum height was 5 nm and 2.5 nm for Ag NPs and MnO2 NPs, respectively. In addition, the novelty lies in the use of the organic compound 5-methoxy-2-mercaptobenzimidazole (MMBI) to synthesis the organic–inorganic nanohybrids which were characterized using FTIR and XRD.
Novel three protic ionic liquids or protic molten salts (PILs) (1a, 1b, and 1c) were obtained from the reactions of hexapyrrolidinocyclotriphosphazenes, N3P3(NC4H8)6 PYR (1), with the gentisic ...(2,5-dihydroxy benzoic), decanoic and boric acids. The structures of PILs were determined by elemental analyses, FTIR and 1H, 13C{1H}, 31P{1H} NMR techniques. The thermal properties of PYR (1) and PILs were described using thermogravimetric analysis (TGA). The results obtained from TGA indicate that the onset temperatures of PYR (1), 1a, 1b, and 1c are 303.38, 256.82, 166.81, and 287.35°C, respectively. Binding interaction of these protic ionic liquids with calf thymus (CT-DNA) and bovine serum albumin (BSA) were evaluated by UV–vis spectrophotometry, fluorescence spectroscopy techniques, and electrophoresis measurements. Biological properties of the compounds were evaluated by using in vitro techniques towards three cancer cell lines (HT29, HeLa, and C6) and one non-cancer cell line, namely Vero. The IC50 data exhibitions that 1b and 1c are the most effective antiproliferative agents against HT29, C6 cells and HeLa cells, respectively. The cytotoxic effects of the compounds were detected to be in a safe level at 75 or 100μg/mL. The analysis of the DNA topoisomerase I relaxing activity indicates that 1a and 1b inhibit topoisomerase I which regulate topological states of DNA strands during the cell process. The apoptotic potential of the compounds at the single cell level indicates that they may inhibit cell proliferation by inducing apoptosis. Immunohistochemistry staining analysis displays that these compounds significantly decreases the level of Bcl-2 in HeLa and HT29 cells while increasing the accumulation of P53. Overall, the potent antiproliferative action, low cytotoxic effect, good solubility in a physiological medium and micro molar range dosage of these compounds reveals that they are likely to be the good drug candidates for pharmacological trials.
The synthesis, characterization and antiproliferative effects of the three new hexapyrrolidinocyclotriphosphazenes-based protic ionic liquids are reported in this paper. It has demonstrated that these salts are potent anticancer drug candidates with low cytotoxic, strong apoptotic, and effective DNA topoisomerase inhibitory characteristics. Display omitted
•Three new hexapyrrolidinocyclotriphosphazenes-based protic ionic liquids (PILs) were synthesized and characterized.•Antiproliferative effects of PILs were tested against HT29, HeLa, and C6 cancer cell lines.•Immunohistochemistry staining analysis was displayed significant decreases at the level of Bcl-2 in HeLa and HT29 cells of PILs.•The PILs may be potential drug candidates for pharmacological trials because of the notable anticancer activity test results.
PDF
