•The importance of the fisheries sector in global food systems is often overlooked.•Nutrition-sensitive fisheries policies are needed to contribute to healthy diets.•Policy focus on aquaculture ...productivity and economic gains inhibits healthy diets.•Complementarity of capture fisheries and aquaculture improves nutrition and health.
The Sustainable Development Goals (SDGs) agenda makes achieving food security and ending malnutrition a global priority. Within this framework, the importance of fisheries in local and global food systems and its contribution to nutrition and health, particularly for the poor are overlooked and undervalued. This paper reviews current fish production and consumption from capture fisheries and aquaculture, highlights opportunities for enhancing healthy diets and outlines key multi-sectoral policy solutions. Mirroring the call for a diversification of agricultural research and investment beyond a few staple grains, it is anticipated that productivity gains for a few farmed aquatic species will not suffice. Capture fisheries and aquaculture have a complementary role to play in increasing fish availability and access, and must be promoted in ways that support measurable nutrition and health gains. This paper argues that the lack of a nutrition-sensitive policy focus on capture fisheries and aquaculture represents an untapped opportunity that must be realised for ensuring sustainable healthy diets for all.
The contribution of seafood to global food security is being increasingly highlighted in policy. However, the extent to which such claims are supported in the current food security literature is ...unclear. This review assesses the extent to which seafood is represented in the recent food security literature, both individually and from a food systems perspective, in combination with terrestrially-based production systems. The results demonstrate that seafood remains under-researched compared to the role of terrestrial animal and plant production in food security. Furthermore, seafood and terrestrial production remain siloed, with very few papers addressing the combined contribution or relations between terrestrial and aquatic systems. We conclude that far more attention is needed to the specific and relative role of seafood in global food security and call for the integration of seafood in a wider interdisciplinary approach to global food system research.
The blue economy provides a sustainability framework for ocean governance, but it is unclear whether narratives are matched by binding financial commitments and disbursements. Amid attention being ...paid to “funding gaps” in the Sustainable Development Goals, a lack of transparency in financial flows means that the blue economy concept risks being co-opted to facilitate further exploitation of ocean spaces and resources without contributing to environmental sustainability or social equity. Here, we analyze blue-economy-labeled money flows disbursed between 2017 and 2021 to identify sources and recipients and potential social equity impacts on the ground. Financing is predominantly disbursed to Europe and Central Asia and skewed toward business development and renewable energy. Our analysis reveals widespread occurrence of “red flags” for social equity outcomes. Although constrained to money flows that actively employ blue economy language, our findings show disconnects between finance and narratives of equity, inclusion, and sustainability. We offer a baseline for critical examination of blue finance flows in delivering equity and environmental sustainability.
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•There is a lack of transparency of blue financial flows•We establish a baseline database of blue economy money flows•Flows are unevenly distributed and red flags for equity are widespread•There is a disconnect between blue economy narratives and action
The blue economy is a concept guiding economic development in oceans, emphasizing environmental sustainability and social equity. Attention has grown to the “funding gap” between investment needed for achieving the Sustainable Development Goals (SDGs), on which the blue economy is based, and existing investment. However, it is unclear what money flows currently exist under the banner of the blue economy and whether they are an optimal use of public and private resources when pursuing sustainable development in oceans. We find that financing is skewed toward business development and offshore wind in Europe and Central Asia, with “red flags” for social equity in 35% of cases, showing that investment currently does not “leave no one behind” (the central promise of the SDGs). Our results provide a benchmark for investors, policymakers, and practitioners to critically examine what blue economy activities they fund or undertake and how they contribute to sustainability and equity goals.
Although the importance of adequate investment for achieving Sustainable Development Goals in the oceans has been championed, it is unclear what funding is currently available. We find that money flows in the blue economy are unevenly distributed across regions and industries, and potentially negative social equity impacts are prevalent. There is a disconnect between aims and actions in the blue economy, posing challenges for furthering economic development in the oceans that simultaneously promotes environmental sustainability and social equity.
A substantial body of evidence supports the utility of antiangiogenesis inhibitors as a strategy to block or attenuate tumor-induced angiogenesis and inhibition of primary and metastatic tumor growth ...in a variety of solid and hematopoietic tumors. Given the requirement of tumors for different cytokine and growth factors at distinct stages of their growth and dissemination, optimal antiangiogenic therapy necessitates inhibition of multiple, complementary, and nonredundant angiogenic targets. 11-(2-Methylpropyl)-12,13-dihydro-2-methyl-8-(pyrimidin-2-ylamino)-4H-indazolo5,4-apyrrolo3,4-ccarbazol-4-one (11b, CEP-11981) is a potent orally active inhibitor of multiple targets (TIE-2, VEGF-R1, 2, and 3, and FGF-R1) having essential and nonredundant roles in tumor angiogenesis and vascular maintenance. Outlined in this article are the design strategy, synthesis, and biochemical and pharmacological profile for 11b, which completed Phase I clinical assessing safety and pharmacokinetics allowing for the initiation of proof of concept studies.
The Systems Biology for Infectious Diseases Research program was established by the U.S. National Institute of Allergy and Infectious Diseases to investigate host-pathogen interactions at a systems ...level. This program generated 47 transcriptomic and proteomic datasets from 30 studies that investigate in vivo and in vitro host responses to viral infections. Human pathogens in the Orthomyxoviridae and Coronaviridae families, especially pandemic H1N1 and avian H5N1 influenza A viruses and severe acute respiratory syndrome coronavirus (SARS-CoV), were investigated. Study validation was demonstrated via experimental quality control measures and meta-analysis of independent experiments performed under similar conditions. Primary assay results are archived at the GEO and PeptideAtlas public repositories, while processed statistical results together with standardized metadata are publically available at the Influenza Research Database (www.fludb.org) and the Virus Pathogen Resource (www.viprbrc.org). By comparing data from mutant versus wild-type virus and host strains, RNA versus protein differential expression, and infection with genetically similar strains, these data can be used to further investigate genetic and physiological determinants of host responses to viral infection.
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