Hox genes encode a family of transcriptional regulators that elicit distinct developmental programmes along the head-to-tail axis of animals. The specific regional functions of individual Hox genes ...largely reflect their restricted expression patterns, the disruption of which can lead to developmental defects and disease. Here, we examine the spectrum of molecular mechanisms controlling Hox gene expression in model vertebrates and invertebrates and find that a diverse range of mechanisms, including nuclear dynamics, RNA processing, microRNA and translational regulation, all concur to control Hox gene outputs. We propose that this complex multi-tiered regulation might contribute to the robustness of Hox expression during development.
A
bstract
Anomalies in semileptonic
B
-meson decays present interesting patterns that might be revealing the shape of the new physics to come. Under the assumption that neutrino and charged lepton ...mass terms are the only sources of flavor violation and given the hierarchy between the two, we find that charged lepton universality violation without charged lepton flavor violation naturally arises. This can account for a deficit of
B
+
→
K
+
μμ
over
B
+
→
K
+
ee
decays with new physics coupled predominantly to muons and a new physics scale of a few TeV. A generic prediction of this scenario is a large enhacement of tauonic
B
decay rates that, in particular, could accommodate an excess in
B
→
D
(∗)
τ ν
. For the most part, the study is carried out in an effective field theory framework with an underlying SU(2)
L
× U(1)
Y
symmetry that emphasizes the model-independent correlations between low- and high-energy observables. As an example, a connection between
B
-decays and top physics is pointed out. To complement the discussion, all possible (spin 0 and 1) leptoquark models are matched to the low-energy field theory so that the effective analysis can be used to survey these candidates for new physics.
A hybrid forecasting methodology to predict one-minute averaged solar irradiance one to ten minutes in advance is presented and evaluated. The methodology combines the use of all-sky images and ...irradiance measurements which are both processed in real time to produce the forecast. Pre-existing image processing techniques are locally adapted to estimate the mean motion of clouds, which is used to predict the future sun disk cover by clouds. Then, the predicted cloud information is converted into a solar irradiance estimate using the proposed model which uses real time measurements to extract its parameters for prediction. The validation of the method is done with a sample of 5238 forecasting time points, spread over a six-month period. The forecast uncertainty is assessed separately for clear, cloudy and partly cloudy days, revealing important characteristics of the model's performance under the different conditions. Under partly cloudy and highly variable conditions, positive forecasting skills with respect to regular persistence are achieved above forecasting horizons of two minutes, with a peak performance of 11.4% for forecasting horizons of six and ten minutes. The proposed model also outperforms a smart persistence model for all time horizons under these sky conditions. The model's ramp detection index (RDI, as defined in Chu et al. (2015)) is also evaluated for high and moderate ramps, achieving RDI indexes between 55 and 62% and between 43 and 49% for high and moderate ramps, respectively. These results show that in challenging highly variable solar irradiance conditions the proposed model is suitable for the very short term solar resource forecasting.
•All sky images are used to estimate the motion of clouds relative to the sun disk.•Cloud motion and online irradiance data are combined to forecast solar irradiance.•The proposed method is used for very short term forecasting, 1–10 min in advance.•Positive forecasting skills as compared to a persistence model are achieved.
We generalize the basis of CP-even chiral effective operators describing a dynamical Higgs sector, to the case in which the Higgs-like particle is light. Gauge and gauge-Higgs operators are ...considered up to mass dimension five. This analysis completes the tool needed to explore at leading order the connection between linear realizations of the electroweak symmetry breaking mechanism — whose extreme case is the Standard Model — and non-linear realizations with a light Higgs-like particle present. It may also provide a model-independent guideline to explore which exotic gauge-Higgs couplings may be expected, and their relative strength to Higgsless observable amplitudes. With respect to fermions, the analysis is reduced by nature to the consideration of those flavor-conserving operators that can be written in terms of pure-gauge or gauge-Higgs ones via the equations of motion, but for the standard Yukawa-type couplings.
A
bstract
We compute the
μ
→
e
conversion in the type-I seesaw model, as a function of the right-handed neutrino mixings and masses. The results are compared with previous computations in the ...literature. We determine the definite predictions resulting for the ratios between the
μ
→
e
conversion rate for a given nucleus and the rate of two other processes which also involve a
μ
−
e
flavour transition:
μ
→
e
γ and
μ
→
eee
. For a quasi-degenerate mass spectrum of right-handed neutrino masses — which is the most natural scenario leading to observable rates — those ratios depend only on the seesaw mass scale, offering a quite interesting testing ground. In the case of sterile neutrinos heavier than the electroweak scale, these ratios vanish typically for a mass scale of order a few TeV. Furthermore, the analysis performed here is also valid down to very light masses. It turns out that planned
μ
→
e
conversion experiments would be sensitive to masses as low as 2 MeV. Taking into account other experimental constraints, we show that future
μ
→
e
conversion experiments will be fully relevant to detect or constrain sterile neutrino scenarios in the 2 GeV−1000 TeV mass range.
Mario Lavista Alonso- Minutti, Ana R
2023, 2023-12-31, 2023-10-17
eBook
Odprti dostop
Composer, pianist, editor, writer, and pedagogue Mario Lavista (1943-2021) was a central figure of the cultural and artistic scene in Mexico and one of the leading Ibero-American composers of his ...generation. His music is often described as evocative and poetic, noted for his meticulous attention to timbre and motivic permutation, and his creative trajectory was characterized by its intersections with the other arts, particularly poetry and painting. Lavista was a relational composer; he did not write music as a private enterprise but for and alongside people with whom he established close relations. Understanding analysis as an affective practice, author Ana R. Alonso-Minutti explores the intertextual connections between the multiple texts--musical or otherwise--that are present in Lavista's music. Alonso-Minutti argues that, through adopting an interdisciplinary and transhistorical approach to music composition, Lavista forged a cosmopolitan imaginary that challenged stereotypes of what Mexican music should sound like. This imaginary becomes a strategy of resistance against imperialist agendas placed upon postcolonial peripheries. Departing from traditional biographical and chronological frameworks that exalt masters and masterworks, the author offers a nuanced, personal narrative informed by conversations with composers, performers, artists, choreographers, poets, writers, and filmmakers. Through an innovative mosaic of methodologies, from archival work, to musical and intertextual analysis, oral history, and (auto)ethnography, this book is the first in-depth study of Lavista's compositional career and offers a contextual panorama of the contemporary music scene in Mexico
A
bstract
As experiment charts new territory at the electroweak scale, the enterprise to characterise all possible theories becomes all the more necessary. In the absence of new particles, this ...ambitious enterprise is attainable and has led to the Higgs Effective Field Theory (HEFT) as the most general characterising framework, containing the Standard Model Effective Field Theory (SMEFT) as a subspace. The characterisation of this theory space led to the dichotomy SMEFT vs. HEFT SMEFT as the two possible realisations of symmetry breaking. The criterion to distinguish these two possibilities is non-local in field space, and phenomena which explore field space beyond the neighbourhood of the vacuum manifold are in a singular position to tell them apart. Cosmology allows for such phenomena, and this work focuses on HEFT SMEFT, the less explored of the two options, to find that first order phase transitions with detectable gravitational wave remnants, domain wall formation and vacuum decay in the far, far distant future can take place and single out HEFT SMEFT. Results in cosmology are put against LHC constraints, and the potential of future ground- and space-based experiments to cover parameter space is discussed.
Lignocellulosic residues are low-cost abundant feedstocks that can be used for industrial applications. However, their recalcitrance currently makes lignocellulose use limited. In natural ...environments, microbial communities can completely deconstruct lignocellulose by synergistic action of a set of enzymes and proteins. Microbial degradation of lignin by fungi, important lignin degraders in nature, has been intensively studied. More recently, bacteria have also been described as able to break down lignin, and to have a central role in recycling this plant polymer. Nevertheless, bacterial deconstruction of lignin has not been fully elucidated yet. Direct analysis of environmental samples using metagenomics, metatranscriptomics, and metaproteomics approaches is a powerful strategy to describe/discover enzymes, metabolic pathways, and microorganisms involved in lignin breakdown. Indeed, the use of these complementary techniques leads to a better understanding of the composition, function, and dynamics of microbial communities involved in lignin deconstruction. We focus on omics approaches and their contribution to the discovery of new enzymes and reactions that impact the development of lignin-based bioprocesses.
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